Search Results - "Ørntoft, T F"

miR-145 induces caspase-dependent and -independent cell death in urothelial cancer cell lines with targeting of an expression signature present in Ta bladder tumors by Ostenfeld, M S, Bramsen, J B, Lamy, P, Villadsen, S B, Fristrup, N, Sørensen, K D, Ulhøi, B, Borre, M, Kjems, J, Dyrskjøt, L, Ørntoft, T F

“…Downregulation of miR-145 in a variety of cancers suggests a possible tumor suppressor function for this microRNA. Here, we show that miR-145 expression is…”
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Expression of MAGE-A3, NY-ESO-1, LAGE-1 and PRAME in urothelial carcinoma by Dyrskjøt, L, Zieger, K, Kissow Lildal, T, Reinert, T, Gruselle, O, Coche, T, Borre, M, Ørntoft, T F

“…Background: The potential for cancer-testis (CT) antigens as targets for immunotherapy in cancer patients has been heavily investigated, and currently cancer…”
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Mutations in the TLR3 signaling pathway and beyond in adult patients with herpes simplex encephalitis by Mørk, N, Kofod-Olsen, E, Sørensen, K B, Bach, E, Ørntoft, T F, Østergaard, L, Paludan, S R, Christiansen, M, Mogensen, T H

“…Herpes simplex encephalitis (HSE) in children has previously been linked to defects in type I interferon production downstream of Toll-like receptor (TLR)3. In…”
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Prognostic significance of aberrantly silenced ANPEP expression in prostate cancer by Sørensen, K D, Abildgaard, M O, Haldrup, C, Ulhøi, B P, Kristensen, H, Strand, S, Parker, C, Høyer, S, Borre, M, Ørntoft, T F

“…Background: Novel biomarkers for prostate cancer (PC) are urgently needed. This study investigates the expression, epigenetic regulation, and prognostic…”
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Global profiling of genes modified by endoplasmic reticulum stress in pancreatic beta cells reveals the early degradation of insulin mRNAs by Pirot, P, Naamane, N, Libert, F, Magnusson, N. E, Ørntoft, T. F, Cardozo, A. K, Eizirik, D. L

“…Aims/hypothesis Pancreatic beta cells respond to endoplasmic reticulum (ER) stress by activating the unfolded protein response. If the stress is prolonged, or…”
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Next-generation sequencing identifies germline MRE11A variants as markers of radiotherapy outcomes in muscle-invasive bladder cancer by Teo, M.T.W., Dyrskjøt, L., Nsengimana, J., Buchwald, C., Snowden, H., Morgan, J., Jensen, J.B., Knowles, M.A., Taylor, G., Barrett, J.H., Borre, M., Ørntoft, T.F., Bishop, D.T., Kiltie, A.E.

“…Muscle-invasive bladder cancer (MIBC) can be cured by radical radiotherapy (RT). We previously found tumour MRE11 expression to be predictive of survival…”
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A high resolution genomic portrait of bladder cancer: correlation between genomic aberrations and the DNA damage response by Schepeler, T, Lamy, P, Hvidberg, V, Laurberg, J R, Fristrup, N, Reinert, T, Bartkova, J, Tropia, L, Bartek, J, Halazonetis, T D, Pan, C-C, Borre, M, Dyrskjøt, L, Ørntoft, T F

“…One major challenge in cancer research is to understand the complex interplay between the DNA damage response (DDR), genomic integrity, and tumor development…”
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Differential gene expression in colon cancer of the caecum versus the sigmoid and rectosigmoid by Birkenkamp-Demtroder, K, Olesen, S H, Sørensen, F B, Laurberg, S, Laiho, P, Aaltonen, L A, Ørntoft, T F

“…Background and aims: There are epidemiological, morphological, and molecular differences between normal mucosa as well as between adenocarcinomas of the right…”
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Dysregulation of the transcription factors SOX4, CBFB and SMARCC1 correlates with outcome of colorectal cancer by Andersen, C L, Christensen, L L, Thorsen, K, Schepeler, T, Sørensen, F B, Verspaget, H W, Simon, R, Kruhøffer, M, Aaltonen, L A, Laurberg, S, Ørntoft, T F

“…The aim of this study was to identify deregulated transcription factors (TFs) in colorectal cancer (CRC) and to evaluate their relation with the recurrence of…”
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Stage-associated overexpression of the ubiquitin-like protein, ISG15, in bladder cancer by ANDERSEN, J. B, AABOE, M, BORDEN, E. C, GOLOUBEVA, O. G, HASSEL, B. A, ØRNTOFT, T. F

“…Bladder cancer is among the most prevalent malignancies, and is characterised by frequent tumour recurrences and localised inflammation, which may promote…”
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Induction of nuclear factor-κB and its downstream genes by TNF-α and IL-1β has a pro-apoptotic role in pancreatic beta cells by Ortis, F, Pirot, P, Naamane, N, Kreins, A. Y, Rasschaert, J, Moore, F, Théâtre, E, Verhaeghe, C, Magnusson, N. E, Chariot, A, Ørntoft, T. F, Eizirik, D. L

“…Aims/hypothesis IL-1β and TNF-α contribute to pancreatic beta cell death in type 1 diabetes. Both cytokines activate the transcription factor nuclear factor-κB…”
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intrauterine metabolic environment modulates the gene expression pattern in fetal rat islets: prevention by maternal taurine supplementation by Reusens, B, Sparre, T, Kalbe, L, Bouckenooghe, T, Theys, N, Kruhøffer, M, Ørntoft, T. F, Nerup, J, Remacle, C

“…Aims/hypothesis Events during fetal life may in critical time windows programme tissue development leading to organ dysfunction with potentially harmful…”
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Analysis of molecular intra-patient variation and delineation of a prognostic 12-gene signature in non-muscle invasive bladder cancer; technology transfer from microarrays to PCR by Dyrskjøt, L, Reinert, T, Novoradovsky, A, Zuiverloon, T C M, Beukers, W, Zwarthoff, E, Malats, N, Real, F X, Segersten, U, Malmström, P-U, Knowles, M, Hurst, C, Sorge, J, Borre, M, Ørntoft, T F

“…Background: Multiple clinical risk factors and genetic profiles have been demonstrated to predict progression of non-muscle invasive bladder cancer; however,…”
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Differential expression of DHHC9 in microsatellite stable and instable human colorectal cancer subgroups by MANSILLA, F, BIRKENKAMP -DEMTRODER, K, KRUHØFFER, M, SØRENSEN, F. B, ANDERSEN, C. L, LAIHO, P, AALTONEN, L. A, VERSPAGET, H. W, ØRNTOFT, T. F

“…Microarray analysis on pooled samples has previously identified ZDHHC9 (DHHC9) to be upregulated in colon adenocarcinoma compared to normal colon mucosa…”
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Pancreatic β-cells activate a JunB ATF3-dependent survival pathway during inflammation by Gurzov, E N, Barthson, J, Marhfour, I, Ortis, F, Naamane, N, Igoillo-Esteve, M, Gysemans, C, Mathieu, C, Kitajima, S, Marchetti, P, Ørntoft, T F, Bakiri, L, Wagner, E F, Eizirik, D L

“…Destruction of insulin-producing pancreatic β-cells by local autoimmune inflammation is a hallmark of type 1 diabetes. Histochemical analysis of pancreases…”
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Low ANXA10 expression is associated with disease aggressiveness in bladder cancer by Munksgaard, P P, Mansilla, F, Brems Eskildsen, A-S, Fristrup, N, Birkenkamp-Demtröder, K, Ulhøi, B P, Borre, M, Agerbæk, M, Hermann, G G, Ørntoft, T F, Dyrskjøt, L

“…Background: Markers for outcome prediction in bladder cancer are urgently needed. We have previously identified a molecular signature for predicting…”
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Gene expression profiling of noninvasive primary urothelial tumours using microarrays by AABOE, M, MARCUSSEN, N, JENSEN, K. M.-E, THYKJAER, T, DYRSKJØT, L, ØRNTOFT, T. F

“…At present, the mechanism leading to bladder cancer is still poorly understood, and our knowledge about early events in tumorigenesis is limited. This study…”
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No evidence of somatic aryl hydrocarbon receptor interacting protein mutations in sporadic endocrine neoplasia by Raitila, A, Georgitsi, M, Karhu, A, Tuppurainen, K, Mäkinen, M J, Birkenkamp-Demtröder, K, Salmenkivi, K, Ørntoft, T F, Arola, J, Launonen, V, Vahteristo, P, Aaltonen, L A

“…Germline mutations in the aryl hydrocarbon receptor interacting protein (AIP) gene were recently observed in patients with pituitary adenoma predisposition…”
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Gene expression signatures for colorectal cancer microsatellite status and HNPCC by KRUHEFFER, M, JENSEN, J. L, MECKLIN, J.-P, JÄRVINEN, H, THYKJAER, T, WIKMAN, F. P, BECH-KNUDSEN, F, JUHOLA, M, NUPPONEN, N. N, LAURBERG, S, ANDERSEN, C. L, AALTONEN, L. A, LAIHO, P, ØRNTOFT, T. F, DYRSKJØT, L, SALOVAARA, R, ARANGO, D, BIRKENKAMP -DEMTRODER, K, SØRENSEN, F. B, CHRISTENSEN, L. L, BUHL, L

“…The majority of microsatellite instable (MSI) colorectal cancers are sporadic, but a subset belongs to the syndrome hereditary non-polyposis colorectal cancer…”
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Frequency of hereditary non-polyposis colorectal cancer in Danish colorectal cancer patients by Katballe, N, Christensen, M, Wikman, F P, Ørntoft, T F, Laurberg, S

“…Background: Hereditary non-polyposis colorectal cancer (HNPCC) is an autosomal dominant cancer syndrome, characterised by familial aggregation of HNPCC related…”
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