Effect of Mirasol pathogen reduction technology system on in vitro quality of MCS+ apheresis platelets

Abstract Reducing the risk of pathogen transmission to transfusion recipients is one of the great concerns in transfusion medicine. Important among the measures suggested to minimise pathogen transmission is pathogen reduction technology (PRT) systems. The present study examined the effects of Miras...

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Published in:	Transfusion and apheresis science Vol. 49; no. 2; pp. 285 - 290
Main Authors:	Mastroianni, Maria Adele, Llohn, Abid Hussain, Akkök, Çiğdem Akalın, Skogheim, Ruby, Ødegaard, Elna Rathe, Nybruket, Monica Jenssen, Flesland, Annika, Mousavi, Seyed Ali
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01-10-2013
Subjects:	Blood Platelets - cytology Blood Platelets - metabolism Blood Preservation - instrumentation Blood Preservation - methods Blood Safety - instrumentation Blood Safety - methods Disinfection - instrumentation Disinfection - methods Female Glucose - metabolism Health technology assessment Hematology, Oncology and Palliative Medicine Humans Hydrogen-Ion Concentration In vitro platelet quality Lactic Acid - metabolism Male MCS+ apheresis platelets Mirasol pathogen reduction technology Plateletpheresis Mirasol pathogen reduction technology In vitro platelet quality MCS+ apheresis platelets
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Summary:	Abstract Reducing the risk of pathogen transmission to transfusion recipients is one of the great concerns in transfusion medicine. Important among the measures suggested to minimise pathogen transmission is pathogen reduction technology (PRT) systems. The present study examined the effects of Mirasol PRT system on MCS+ apheresis platelets in vitro quality measures during a seven-day storage period at 22 °C. Statistical analysis indicated no significant difference in platelet concentrations between the control and treated platelet concentrates (PCs) during the storage period. Glucose and lactate levels were measured to determine metabolic activities of control and treated platelets. In both control and treated platelets, the amount of glucose consumed and lactate produced increased significantly with storage time, but glucose consumption and lactate production rates were significantly higher in treated platelets compared with control platelets. The mean pH of treated PCs was decreased at all time points relative to control PCs but remained within acceptable limits. The expression of P-selectin was also higher in Mirasol PRT treated platelets throughout the storage period, but differences were not statistically significant on Days 1 and 4. Finally, visual inspection of swirling indicated that Mirasol PRT treatment of platelets is associated with platelet shape change. Overall, our results show that MCS+ apheresis platelets treated with Mirasol PRT can preserve adequate in vitro properties for at least 5 days of storage.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23
ISSN:	1473-0502 1878-1683
DOI:	10.1016/j.transci.2013.06.009