Search Results - "ØRSKOV, Hans"

Cotreatment with Pegvisomant and a Somatostatin Analog (SA) in SA-Responsive Acromegalic Patients by Madsen, Michael, Poulsen, Per L, Ørskov, Hans, Møller, Niels, Jørgensen, Jens O. L

“…Context: Cotreatment of acromegaly with pegvisomant and a somatostatin analog (SA) has proven feasible. Previous studies in the field have focused on patients…”
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Fasting Unmasks a Strong Inverse Association between Ghrelin and Cortisol in Serum: Studies in Obese and Normal-Weight Subjects by Espelund, Ulrick, Hansen, Troels Krarup, Højlund, Kurt, Beck-Nielsen, Henning, Clausen, Jes Thorn, Hansen, Birgit Sehested, Ørskov, Hans, Jørgensen, Jens Otto Lunde, Frystyk, Jan

“…Administration of ghrelin, the endogenous ligand for the GH secretagogue receptor, stimulates not only GH secretion but also appetite and food intake in…”
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A highly sensitive and specific assay for determination of IGF-I bioactivity in human serum by Chen, Jian-Wen, Ledet, Thomas, Orskov, Hans, Jessen, Niels, Lund, Sten, Whittaker, Jonathan, De Meyts, Pierre, Larsen, Maj Britt, Christiansen, Jens Sandahl, Frystyk, Jan

“…At present, the circulating bioactivity of insulin-like growth factor I (IGF-I) is estimated by immunological measurements of IGF-I levels. However,…”
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The Impact of Pegvisomant Treatment on Substrate Metabolism and Insulin Sensitivity in Patients with Acromegaly by Lindberg-Larsen, Rune, Møller, Niels, Schmitz, Ole, Nielsen, Søren, Andersen, Marianne, Ørskov, Hans, Jørgensen, Jens O. L.

“…Context: Pegvisomant is a specific GH receptor antagonist that is able to normalize serum IGF-I concentrations in most patients with acromegaly. The impact of…”
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Circulating levels of pegvisomant and endogenous growth hormone during prolonged pegvisomant therapy in patients with acromegaly by Madsen, Michael, Fisker, Sanne, Feldt-Rasmussen, Ulla, Andreassen, Mikkel, Kristensen, Lars Østergaard, Ørskov, Hans, Jørgensen, Jens Otto L.

“…Summary Objective To investigate whether pegvisomant treatment in acromegaly induces gradual elevations in endogenous serum growth hormone (GH) levels and…”
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Ghrelin immunoreactivity in human plasma is suppressed by somatostatin by Nørrelund, Helene, Hansen, Troels K., Ørskov, Hans, Hosoda, Hiroshi, Kojima, Masayasu, Kangawa, Kenji, Weeke, Jørgen, Møller, Niels, Christiansen, Jens S., Jørgensen, Jens Otto L.

“…Summary objective Ghrelin was recently identified as a specific endogenous ligand for the growth hormone secretagogue receptor (GHS‐R). This new hormone was…”
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Elevated free IGF2 levels in localized, early-stage breast cancer in women by Espelund, Ulrick, Cold, Søren, Frystyk, Jan, Ørskov, Hans, Flyvbjerg, Allan

“…ObjectiveEpidemiological studies imply an association between circulating IGF1 and breast cancer, whereas the role of IGF2, which also acts on the IGF1…”
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Cubilin is an albumin binding protein important for renal tubular albumin reabsorption by Birn, H, Fyfe, J C, Jacobsen, C, Mounier, F, Verroust, P J, Orskov, H, Willnow, T E, Moestrup, S K, Christensen, E I

“…Using affinity chromatography and surface plasmon resonance analysis, we have identified cubilin, a 460-kDa receptor heavily expressed in kidney proximal…”
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Free Rather than Total Circulating Insulin-Like Growth Factor-I Determines the Feedback on Growth Hormone Release in Normal Subjects by Chen, Jian-Wen, Højlund, Kurt, Beck-Nielsen, Henning, Sandahl Christiansen, Jens, Ørskov, Hans, Frystyk, Jan

“…Pituitary GH secretion is feedback regulated by circulating IGF-I. However, it remains to be determined whether the feedback control is mediated through…”
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Continuous Glucose Monitoring in Interstitial Subcutaneous Adipose Tissue and Skeletal Muscle Reflects Excursions in Cerebral Cortex by NIELSEN, Jannik Kruse, DJURHUUS, Christian Born, GRAVHOLT, Claus Højbjerg, CARUS, Andreas Christiansen, GRANILD-JENSEN, Jacob, HANS, RSKOV, CHRISTIANSEN, Jens Sandahl

“…Continuous Glucose Monitoring in Interstitial Subcutaneous Adipose Tissue and Skeletal Muscle Reflects Excursions in Cerebral Cortex Jannik Kruse Nielsen ,…”
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Cardiovascular disease and insulin-like growth factor I by Frystyk, Jan, Ledet, Thomas, Møller, Niels, Flyvbjerg, Allan, Orskov, Hans

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Physical capacity influences the response of insulin-like growth factor and its binding proteins to training by Rosendal, Lars, Langberg, Henning, Flyvbjerg, Allan, Frystyk, Jan, Orskov, Hans, Kjar, Michael

“…1  Sports Medicine Research Unit and Copenhagen Muscle Research Centre, Bispebjerg Hospital, DK-2400 Copenhagen; 2  National Institute of Occupational Health,…”
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Acute Hyperinsulinemia Restrains Endotoxin-induced Systemic Inflammatory Response by Brix-Christensen, Vibeke, Andersen, Søren Kæseler, Andersen, René, Mengel, Annette, Dyhr, Thomas, Andersen, Niels Trolle, Larsson, Anders, Schmitz, Ole, Ørskov, Hans, Tønnesen, Else

“…Background Intensive insulin therapy in critically ill patients reduces morbidity and mortality. The current study elucidates whether acute hyperinsulinemia…”
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Free insulin-like growth factors (IGF-I and IGF-II) in human serum by Frystyk, Jan, Skjærbæk, Christian, Dinesen, Bo, Ørskov, Hans

“…Using ultrafiltration by centrifugation we have isolated the free, unbound fractions of insulin-like growth factor I and II (free IGF-I and IGF-II) in human…”
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Sustained low-dose growth hormone therapy optimizes bioactive insulin-like growth factor-I level and may enhance CD4 T-cell number in HIV infection by Andersen, Ove, Hansen, Birgitte Rønde, Troensegaard, William, Flyvbjerg, Allan, Madsbad, Sten, Ørskov, Hans, Nielsen, Jens Ole, Iversen, Johan, Haugaard, Steen B

“…High-dose recombinant human growth hormone (rhGH) (2-6 mg/day) regimes may facilitate T-cell restoration in patients infected with human immunodeficiency virus…”
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Acute Growth Hormone Administration Causes Exaggerated Increases in Plasma Lactate and Glycerol during Moderate to High Intensity Bicycling in Trained Young Men by Lange, Kai Henrik Wiborg, Larsson, Benny, Flyvbjerg, Allan, Dall, Rolf, Bennekou, Morten, Rasmussen, Michael Højby, Ørskov, Hans, Kjær, Michael

“…We studied the acute effects of a single, sc GH dose on exercise performance and metabolism during bicycling. Seven highly trained men [age, 26 ± 1 yr (mean ±…”
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Development and Clinical Evaluation of a Novel Immunoassay for the Binary Complex of IGF-I and IGF-Binding Protein-1 in Human Serum by Frystyk, Jan, Højlund, Kurt, Rasmussen, Kirsten Nyborg, Jørgensen, Søren Peter, Wildner-Christensen, Mette, Ørskov, Hans

“…Correlation studies have suggested that IGF-binding protein (IGFBP)-1 is a dynamic regulator of free IGF-I. To further study this, we developed a monoclonal…”
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Effects of 2 wk of GH administration on 24-h indirect calorimetry in young, healthy, lean men by Hansen, Mette, Morthorst, Rikke, Larsson, Benny, Flyvbjerg, Allan, Rasmussen, Michael Højby, Orskov, Hans, Astrup, Arne, Kjaer, Michael, Lange, Kai Henrik Wiborg

“…The present study was designed as a randomized, double-blind placebo (Plc)-controlled study to determine the effect of 2 wk of growth hormone administration…”
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No effect of growth hormone administration on substrate oxidation during exercise in young, lean men by Hansen, Mette, Morthorst, Rikke, Larsson, Benny, Dall, Rolf, Flyvbjerg, Allan, Rasmussen, Michael Højby, Ørskov, Hans, Kjær, Michael, Lange, Kai Henrik Wiborg

“…The purpose of this study was to examine the effects of increased fat availability induced by growth hormone (GH) administration on the oxidative metabolism…”
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Kinetics and secretion of placental growth hormone around parturition by Fuglsang, Jens, Sandager, Puk, Møller, Niels, Fisker, Sanne, Ørskov, Hans, Ovesen, Per

“…Objective: During pregnancy, placental growth hormone (PGH) is secreted into the maternal circulation, replacing pituitary GH. It is controversial whether PGH…”
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