Melatonin prevents radiation‐induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis

Melatonin prevents radiation‐induced oxidative stress and periodontal tissue breakdown in irradiated rats with experimental periodontitis

Background and Objective The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis. Material and Methods Sixty male Sprague Dawley rats were divided into s...

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Published in:Journal of periodontal research Vol. 52; no. 3; pp. 438 - 446
Main Authors: Köse, O., Arabaci, T., Kizildag, A., Erdemci, B., Özkal Eminoğlu, D., Gedikli, S., Özkanlar, S., Zihni, M., Albayrak, M., Kara, A., Kermen, E.
Format: Journal Article
Language:English
Published: United States Wiley Subscription Services, Inc 01-06-2017
Subjects:
Alveolar bone
Animals
antioxidants
Antioxidants - pharmacology
Bone loss
Collagen (type I)
Dentistry
Deoxyguanosine
Disease Models, Animal
experimental periodontitis
Gum disease
host modulation therapy
Interleukin-1beta - blood
Male
Malondialdehyde
Melatonin
Melatonin - pharmacology
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - radiation effects
Periodontitis
Periodontitis - metabolism
Periodontitis - pathology
Periodontium - metabolism
Periodontium - pathology
Radiation
Radiation therapy
radiotherapy
Radiotherapy - adverse effects
Rats
Rats, Sprague-Dawley
Rodents
Tumor Necrosis Factor-alpha - blood
radiotherapy
experimental periodontitis
antioxidants
host modulation therapy
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Summary:Background and Objective The aim of this study was to analyze the biochemical and histochemical effects of radiation therapy and protective melatonin administration on periodontal tissues in rats with experimental periodontitis. Material and Methods Sixty male Sprague Dawley rats were divided into six groups, as follows: control; experimental periodontitis (Ped); radiotherapy administration (Rt); experimental periodontitis and exposure to irradiation (Ped‐Rt); radiotherapy and protective melatonin administration (Rt‐Mel); and periodontitis, radiation therapy and protective melatonin administration (Ped‐Rt‐Mel). The rats were killed at the end of the experimental procedure, and the oxidative stress level and periodontal destruction were compared among the groups. Results The oxidative stress index and the levels of 8‐hydroxy‐2′‐deoxyguanosine, malondialdehyde and C‐terminal telopeptide of type I collagen were found to be significantly higher in the Ped‐Rt group compared with the Ped group (p < 0.05), and the levels were lower in the Ped‐Rt‐Mel group than in the Ped‐Rt group (p < 0.05). Alveolar bone destruction and attachment level were also significantly lower in the Ped‐Rt‐Mel group than in the Ped‐Rt group (p < 0.05). Conclusion It was found that radiotherapy increased oxidative stress, the periodontal attachment level and alveolar bone loss, and protective melatonin administration significantly reduced the oxidative parameters and prevented periodontal damage in irradiated rats with experimental periodontitis. Further research is needed regarding the use of systemic melatonin administration before radiation therapy.
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ISSN:0022-3484
1600-0765
DOI:10.1111/jre.12409