Hypoxic-ischemic encephalopathy: Correlation of serial MRI and outcome

Twenty-four patients with hypoxic-ischemic encephalopathy were examined with serial magnetic resonance imaging up to 4 years of age. Magnetic resonance imaging studies were performed in the neonatal period, at the fourth month and the fourth year of age, and the findings were compared with the patie...

Full description

Saved in:

Bibliographic Details
Published in:	Pediatric neurology Vol. 31; no. 4; pp. 267 - 274
Main Authors:	Belet, Nurşen, Belet, Umit, İncesu, L.ütfi, Uysal, Serap, Özinal, Satılmış, Keskin, T.ülay, Sunter, A.Tevfik, Küçüködük, S.̧ükrü
Format:	Journal Article
Language:	English
Published:	New York, NY Elsevier Inc 01-10-2004 Elsevier
Subjects:	Biological and medical sciences Brain - growth & development Brain - pathology Brain Diseases - etiology Child Development Developmental Disabilities - etiology Female Follow-Up Studies Humans Hypoxia-Ischemia, Brain - complications Hypoxia-Ischemia, Brain - pathology Infant, Newborn Investigative techniques, diagnostic techniques (general aspects) Magnetic Resonance Imaging Male Medical sciences Nervous system Neurologic Examination Neurology Predictive Value of Tests Prospective Studies Radiodiagnosis. Nmr imagery. Nmr spectrometry Vascular diseases and vascular malformations of the nervous system Oxygen Nervous system diseases Prognosis Ischemia Encephalopathy Central nervous system disease Cardiovascular disease Environmental factor Medical imagery Hypoxia Nuclear magnetic resonance imaging Cerebral disorder
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Twenty-four patients with hypoxic-ischemic encephalopathy were examined with serial magnetic resonance imaging up to 4 years of age. Magnetic resonance imaging studies were performed in the neonatal period, at the fourth month and the fourth year of age, and the findings were compared with the patients' neurodevelopmental outcome at the fourth year of age. Periventricular signal alterations and deep gray matter involvement were usually evident in the initial magnetic resonance imaging studies, and encephalomalacia, periventricular leukomalacia, and atrophy were the common findings on follow-up magnetic resonance imaging studies. In the patients with hypoxic-ischemic encephalopathy, some correlation between magnetic resonance imaging findings and neurodevelopmental outcome was recognized. The patients with deep gray matter involvement on the initial magnetic resonance imaging had a poor prognosis, and the ones with normal magnetic resonance imaging findings had a favorable neurodevelopmental outcome. On the follow-up magnetic resonance imaging findings, encephalomalacia and periventricular leukomalacia were associated with poor neurodevelopmental outcome. In predicting the neurologic outcome at 4 years of age, magnetic resonance imaging findings of the neonatal period had the highest negative predictive value, whereas magnetic resonance imaging findings at 4 months of age and 4 years of age had the highest positive predictive value.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0887-8994 1873-5150
DOI:	10.1016/j.pediatrneurol.2004.04.011