Search Results - "Özcan, Gülnihal"

SCUBE2 as a Marker of Resistance to Taxane-based Neoadjuvant Chemotherapy and a Potential Therapeutic Target in Breast Cancer by Özcan, Gülnihal

“…Taxane-based neoadjuvant chemotherapy is the most common neoadjuvant approach in breast cancer, especially in human epidermal growth factor receptor 2…”
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Extracranial transport of brain lymphatics via cranial nerve in human by Çavdar, Safiye, Altınöz, Damlasu, Dilan Demir, Tevriz, Ali Gürses, İlke, Özcan, Gülnihal

“…[Display omitted] Extracranial waste transport from the brain interstitial fluid to the deep cervical lymph node (dCLN) is not extensively understood. The…”
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Brain lymphatic vessels accompanying meningeal arteries in the human by Çavdar, Safiye, Altınöz, Damlasu, Demir, Tevriz Dilan, Bayraktaroğlu, Acar, Gürses, İlke Ali, Özcan, Gülnihal

“…Recent studies showed the connection between cerebrospinal fluid (CSF) and deep cervical lymph nodes (dCLN) via lymphatic vessels (LV)s. These LVs accompany…”
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Cell Contact-dependent Functional Selectivity of β2-Adrenergic Receptor Ligands in Stimulating cAMP Accumulation and Extracellular Signal-regulated Kinase Phosphorylation by Kaya, Ali I., Onaran, H. Ongun, Özcan, Gülnihal, Ambrosio, Caterina, Costa, Tommaso, Balli, Sezen, Uğur, Özlem

“…Activation of β2-adrenegic receptor (β2-AR) leads to an increase in intracellular cAMP and activation of ERK. These two signals are activated by the…”
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β2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions by ÖNER, S. Sadik, KAYA, Ali I, ONARAN, H. Ongun, ÖZCAN, Gülnihal, UGUR, Özlem

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PTCH1 and CTNNB1 emerge as pivotal predictors of resistance to neoadjuvant chemotherapy in ER+/HER2- breast cancer by Ozcan, Gulnihal

“…Endeavors in the molecular characterization of breast cancer opened the doors to endocrine therapies in ER+/HER2- breast cancer, increasing response rates…”
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Comprehensive bioinformatic analysis reveals a cancer-associated fibroblast gene signature as a poor prognostic factor and potential therapeutic target in gastric cancer by Ucaryilmaz Metin, Cemre, Ozcan, Gulnihal

“…Abstract Background Gastric cancer is one of the deadliest cancers, currently available therapies have limited success. Cancer-associated fibroblasts (CAFs)…”
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The hypoxia-inducible factor-1α in stemness and resistance to chemotherapy in gastric cancer: Future directions for therapeutic targeting by Ozcan, Gulnihal

“…Hypoxia-inducible factor-1α (HIF-1α) is a crucial mediator of intra-tumoral heterogeneity, tumor progression, and unresponsiveness to therapy in tumors with…”
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Functional genomics reveals an off-target dependency of drug synergy in gastric cancer therapy by Leylek, Ozen, Honeywell, Megan E., Lee, Michael J., Hemann, Michael T., Ozcan, Gulnihal

“…Background Integrating molecular-targeted agents into combination chemotherapy is transformative for enhancing treatment outcomes in cancer. However, realizing…”
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Cancer-associated fibroblasts: protagonists of the tumor microenvironment in gastric cancer by Ozmen, Ece, Demir, Tevriz Dilan, Ozcan, Gulnihal

“…Enhanced knowledge of the interaction of cancer cells with their environment elucidated the critical role of tumor microenvironment in tumor progression and…”
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β 2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions by Öner, Ş. Sadık, Kaya, Ali İ., Onaran, H. Ongun, Özcan, Gülnihal, Uğur, Özlem

“…Membrane rafts and caveolae are specialized microdomains of the cell membrane that form physical platforms for compartmentalization of signalling molecules…”
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Abstract P023: Achieving synergism in combination chemotherapy for gastric cancer treatment by Leylek, Ozen, Ozcan, Gulnihal

“…Abstract Gastric cancer (GC) is the fifth most common cancer and the fourth leading cause of deaths from cancer. Although the combination of conventional…”
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HEK-293 kültür hücrelerinde beta2-adrenerjik reseptör ligandlarının Camp ve erk yanıtları bakımından hücre kontaktına bağlı koşullu fonksiyonel seçiciliği by Özcan, Gülnihal

“…G proteinlerine kenetli reseptörler (GPKR'ler), hücre dışı sinyallerin hücre içine iletilmesini sağlayan hücre yüzeyi reseptörlerinin en büyük ailesidir…”
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Preclinical and clinical development of siRNA-based therapeutics by Ozcan, Gulnihal, Ozpolat, Bulent, Coleman, Robert L., Sood, Anil K., Lopez-Berestein, Gabriel

“…The discovery of RNA interference, first in plants and Caenorhabditis elegans and later in mammalian cells, led to the emergence of a transformative view in…”
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The HIF-1α as a Potent Inducer of the Hallmarks in Gastric Cancer by Ucaryilmaz Metin, Cemre, Ozcan, Gulnihal

“…Hypoxia is the principal architect of the topographic heterogeneity in tumors. Hypoxia-inducible factor-1α (HIF-1α) reinforces all hallmarks of cancer and…”
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Resorufin Enters the Photodynamic Therapy Arena: A Monoamine Oxidase Activatable Agent for Selective Cytotoxicity by Almammadov, Toghrul, Atakan, Gizem, Leylek, Ozen, Ozcan, Gulnihal, Gunbas, Gorkem, Kolemen, Safacan

“…A red-absorbing, water-soluble, and iodinated resorufin derivative (R1) that can be selectively activated with a monoamine oxidase (MAO) enzyme was…”
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beta2-Adrenoceptor, Gs and adenylate cyclase coupling in purified detergent-resistant, low density membrane fractions by Oner, S Sadik, Kaya, Ali I, Onaran, H Ongun, Ozcan, Gülnihal, Uğur, Ozlem

“…Membrane rafts and caveolae are specialized microdomains of the cell membrane that form physical platforms for compartmentalization of signalling molecules…”
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Adverse Drug Reaction Reporting Pattern in Turkey: Analysis of the National Database in the Context of the First Pharmacovigilance Legislation by Ozcan, Gulnihal, Aykac, Emel, Kasap, Yelda, Nemutlu, Nergiz T., Sen, Ebru, Aydinkarahaliloglu, N. Demet

“…Introduction In Turkey, pharmacovigilance began in 1985. A fully structured adverse drug reaction (ADR)-reporting system was established with the publication…”
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Various Phosphodiesterase Activities in Different Regions of the Heart Alter the Cardiac Effects of Nitric Oxide by Demirel-Yilmaz, Emine, Cenik, Basar, Ozcan, Gulnihal, Derici, Mehmet Kursat

“…The modulation of cardiac functions by nitric oxide (NO) was established. This study examined the influences of phosphodiesterase (PDE) inhibitors on the…”
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Adverse Drug Reaction Reporting Pattern in Turkey: Analysis of the National Database in the Context of the First Pharmacovigilance Legislation by Ozcan, Gulnihal, Aykac, Emel, Kasap, Yelda, Nemutlu, Nergiz T., Sen, Ebru, Aydinkarahaliloglu, N. Demet

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