Traditional Chinese medicine practices used in COVID-19 (Sars-cov 2/Coronavirus-19) treatment in clinic and their effects on the cardiovascular system

The aim of this study was to evaluate the effectiveness of plants used in the formulations of traditional Chinese medicine (TCM), which were also used in clinical trials to treat patients with the novel coronavirus COVID-19, and to assess their effects on the cardiovascular system. A literature revi...

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Bibliographic Details
Published in:	Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir Vol. 48; no. 4; pp. 410 - 424
Main Authors:	Akalın, Emine, Ekici, Miraç, Alan, Zinar, Özbir Elevli, Elif, Yaman Bucak, Aysenur, Aobuliaikemu, Nuerbiye, Üresin, Ali Yağız
Format:	Journal Article
Language:	English
Published:	Turkey KARE Publishing 01-06-2020
Subjects:	Animals Anti-Arrhythmia Agents - pharmacology Anti-Arrhythmia Agents - therapeutic use Anti-Arrhythmia Agents - toxicity Anti-Inflammatory Agents - pharmacology Anti-Inflammatory Agents - therapeutic use Anti-Inflammatory Agents - toxicity Anticholesteremic Agents - pharmacology Anticholesteremic Agents - therapeutic use Anticholesteremic Agents - toxicity Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Antihypertensive Agents - toxicity antiviral Antiviral Agents - pharmacology Antiviral Agents - therapeutic use Antiviral Agents - toxicity Calcium Channel Blockers - pharmacology Calcium Channel Blockers - therapeutic use Calcium Channel Blockers - toxicity Cardiovascular System - drug effects cardiovascular system; covid-19; immunomodulator; traditional chinese medicine Coronavirus Infections - therapy COVID-19 Drug Interactions Drugs, Chinese Herbal - pharmacology Drugs, Chinese Herbal - therapeutic use Drugs, Chinese Herbal - toxicity Humans Medicine, Chinese Traditional Pandemics Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Platelet Aggregation Inhibitors - toxicity Pneumonia, Viral - therapy Vasodilator Agents - pharmacology Vasodilator Agents - therapeutic use Vasodilator Agents - toxicity
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Summary:	The aim of this study was to evaluate the effectiveness of plants used in the formulations of traditional Chinese medicine (TCM), which were also used in clinical trials to treat patients with the novel coronavirus COVID-19, and to assess their effects on the cardiovascular system. A literature review of PubMed, ResearchGate, ScienceDirect, the Cochrane Library, and TCM monographs was conducted and the effects of the plants on the cardiovascular system and the mechanisms of action in COVID-19 treatment were evaluated. The mechanism of action, cardiovascular effects, and possible toxicity of 10 plants frequently found in TCM formulations that were used in the clinical treatment of COVID-19 were examined. TCM formulations that had been originally developed for earlier viral diseases have been used in COVID-19 treatment. Despite the effectiveness seen in laboratory and animal studies with the most commonly used plants in these formulations, the clinical studies are currently insufficient according to standard operating procedures. More clinical studies are needed to understand the safe clinical use of traditional plants.
ISSN:	1308-4488 1016-5169
DOI:	10.5543/tkda.2020.03374