Search Results - "Özbil, Mehmet"

Structural rearrangement of Neisseria meningitidis transferrin binding protein A (TbpA) prior to human transferrin protein (hTf) binding by DURAN, Gizem Nur, ÖZBİL, Mehmet

“…Gram-negative bacterium Neisseria meningitidis, responsible for human infectious disease meningitis, acquires the iron (Fe 3+ ) ion needed for its survival…”
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Strigolactone Analogs: Two New Potential Bioactiphores for Glioblastoma by Antika, Gizem, Cinar, Zeynep Özlem, Seçen, Esma, Özbil, Mehmet, Tokay, Esra, Köçkar, Feray, Prandi, Cristina, Tumer, Tugba Boyunegmez

“…Strigolactones (SLs), carotenoid-derived phytohormones, control the plant response and signaling pathways for stressful conditions. In addition, they impact…”
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Selagibenzophenone B and Its Derivatives: SelB‑1, a Dual Topoisomerase I/II Inhibitor Identified through In Vitro and In Silico Analyses by Dönmez, Serhat, Lapinskaite, Ringaile, Atalay, Hazal Nazlican, Tokay, Esra, Kockar, Feray, Rycek, Lukas, Özbil, Mehmet, Tumer, Tugba Boyunegmez

“…The development of multitargeted drugs represents an innovative approach to cancer treatment, aiming to enhance drug effectiveness while minimizing side…”
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Effects of Strigolactones on NLRP3 Activation, Nitrosative Stress, and Antioxidant Mox Phenotype: In Vitro and In Silico Evidence by Antika, Gizem, Cinar, Zeynep Özlem, Dönmez, Serhat, Seçen, Esma, Özbil, Mehmet, Prandi, Cristina, Tumer, Tugba Boyunegmez

“…Phytohormones have significant roles in redox metabolism, inflammatory responses, and cellular survival mechanisms within the microenvironment of the mammalian…”
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Comparison of clinically approved molecules on SARS-CoV-2 drug target proteins: a molecular docking study by Çubuk, Hasan, Özbİl, Mehmet

“…The new type of coronavirus, SARS-CoV-2 has affected more than 22.6 million people worldwide. Since the first day the virus was spotted in Wuhan, China,…”
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In silico analysis of SARS-CoV-2 spike protein N501Y and N501T mutation effects on human ACE2 binding by Çubuk, Hasan, Özbi̇l, Mehmet

“…The SARS-CoV-2 is an RNA-based virus and the most vital step of its survival is the attachment to hACE2 through its spike protein. Although SARS-CoV-2 has the…”
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Synthesis, molecular modeling and antiviral activity of novel 5-fluoro-1H-indole-2,3-dione 3-thiosemicarbazones by Sevinçli, Zekiye Şeyma, Duran, Gizem Nur, Özbil, Mehmet, Karalı, Nilgün

“…[Display omitted] •26 new 1-alkylated 5-fluoroisatin 3-thiosemicarbazone derivatives were synthesized.•Some derivatives were found effective against herpes…”
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Exome data of developmental and epileptic encephalopathy patients reveals de novo and inherited pathologic variants in epilepsy-associated genes by Çapan, Özlem Yalçın, Yapıcı, Zuhal, Özbil, Mehmet, Çağlayan, Hande S.

“…•Nine patients harbor pathological (P) or likely pathological (LP) mutations (31%) and three patients have VUS variants (10%) out of 29 DEE patients.•De novo…”
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Antiviral activity and molecular modeling studies on 1H-indole-2,3-diones carrying a naphthalene moiety by Soylu-Eter, Özge, Duran, Gizem Nur, Özbil, Mehmet, Göktaş, Füsun, Cihan-Üstündağ, Gökçe, Karalı, Nilgün

“…•1H-indole-2,3-diones (2a-f) bearing a naphthalene ring were synthesized.•The antiviral effects of 2a-f were evaluated against different DNA and RNA…”
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Molecular mechanism of activation of human musk receptors OR5AN1 and OR1A1 by (R)-muscone and diverse other musk-smelling compounds by Ahmed, Lucky, Zhang, Yuetian, Block, Eric, Buehl, Michael, Corr, Michael J., Cormanich, Rodrigo A., Gundala, Sivaji, Matsunami, Hiroaki, O’Hagan, David, Ozbil, Mehmet, Pan, Yi, Sekharan, Sivakumar, Ten, Nicholas, Wang, Mingan, Yang, Mingyan, Zhang, Qingzhi, Zhang, Ruina, Batista, Victor S., Zhuang, Hanyi

“…Understanding olfaction at the molecular level is challenging due to the lack of crystallographic models of odorant receptors (ORs). To better understand the…”
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Computational insight into the phthalocyanine-DNA binding via docking and molecular dynamics simulations by Ozalp, Lalehan, Sağ Erdem, Safiye, Yüce-Dursun, Başak, Mutlu, Özal, Özbil, Mehmet

“…[Display omitted] •Quaternary metallophthalocyanines bind to DNA with good docking scores.•Attractive charge and π-anion interactions largely account for the…”
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Novel N‐(1‐thia‐4‐azaspiro[4.5]decan‐4‐yl)carboxamide derivatives as potent and selective influenza virus fusion inhibitors by Göktaş, Füsun, Özbil, Mehmet, Cesur, Nesrin, Vanderlinden, Evelien, Naesens, Lieve, Cesur, Zafer

“…Hemagglutinin is the surface protein of the influenza virus that mediates both binding and penetration of the virus into host cells. We here report on the…”
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HNF1A-MODY Mutations in Nuclear Localization Signal Impair HNF1A-Import Receptor KPNA6 Interactions by Fareed, Fareed M. A., Korulu, Sirin, Özbil, Mehmet, Çapan, Özlem Yalçın

“…Mutations in hepatocyte nuclear factor (HNF)1A gene cause the most common form of Maturity-onset diabetes of the young (MODY), a monogenic subtype of diabetes…”
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Implausibility of the vibrational theory of olfaction by Block, Eric, Jang, Seogjoo, Matsunami, Hiroaki, Sekharan, Sivakumar, Dethier, Bérénice, Ertem, Mehmed Z., Gundala, Sivaji, Pan, Yi, Li, Shengju, Li, Zhen, Lodge, Stephene N., Ozbil, Mehmet, Jiang, Huihong, Penalb, Sonia F., Batista, Victor S., Zhuang, Hanyi

“…The vibrational theory of olfaction assumes that electron transfer occurs across odorants at the active sites of odorant receptors (ORs), serving as a…”
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Disulfide bridges remain intact while native insulin converts into amyloid fibrils by Kurouski, Dmitry, Washington, Jacqueline, Ozbil, Mehmet, Prabhakar, Rajeev, Shekhtman, Alexander, Lednev, Igor K

“…Amyloid fibrils are β-sheet-rich protein aggregates commonly found in the organs and tissues of patients with various amyloid-associated diseases…”
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An Extended Polyanion Activation Surface in Insulin Degrading Enzyme by Song, Eun Suk, Ozbil, Mehmet, Zhang, Tingting, Sheetz, Michael, Lee, David, Tran, Danny, Li, Sheng, Prabhakar, Rajeev, Hersh, Louis B, Rodgers, David W

“…Insulin degrading enzyme (IDE) is believed to be the major enzyme that metabolizes insulin and has been implicated in the degradation of a number of other…”
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Experimental and Computational Evidence of Metal‑O2 Activation and Rate-Limiting Proton-Coupled Electron Transfer in a Copper Amine Oxidase by Liu, Yi, Mukherjee, Arnab, Nahumi, Nadav, Ozbil, Mehmet, Brown, Doreen, Angeles-Boza, Alfredo M, Dooley, David M, Prabhakar, Rajeev, Roth, Justine P

“…The mechanism of O2 reduction by copper amine oxidase from Arthrobacter globiformus (AGAO) is analyzed in relation to the cobalt-substituted protein. The…”
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Mechanism of peptide hydrolysis by co-catalytic metal centers containing leucine aminopeptidase enzyme: a DFT approach by Zhu, Xiaoxia, Barman, Arghya, Ozbil, Mehmet, Zhang, Tingting, Li, Shanghao, Prabhakar, Rajeev

“…In this density functional theory study, reaction mechanisms of a co-catalytic binuclear metal center (Zn1–Zn2) containing enzyme leucine aminopeptidase for…”
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R1205H (Vicenza) causes conformational changes in the von Willebrand factor D'D3 domains and enhances von Willebrand factor binding to clearance receptors LRP1 and SR-AI by Atiq, Ferdows, Rawley, Orla, O'Sullivan, Jamie M, Özbil, Mehmet, Doherty, Dearbhla, Cooke, Niamh, Terraube, Virginie, Chion, Alain, Amin, Aamir, Hulshof, Anne-Marije, Baci, Bogdan, Byrne, Ciara, Aburawi, Hanan E, Lillicrap, David, O'Donnell, James S

“…von Willebrand factor (VWF)-R1205H variant (Vicenza) results in markedly enhanced VWF clearance in humans that has been shown to be largely…”
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R1205H (Vicenza) causes conformational changes in the von Willebrand factor D′D3 domains and enhances von Willebrand factor binding to clearance receptors LRP1 and SR-AI by Atiq, Ferdows, Rawley, Orla, O’Sullivan, Jamie M., Özbil, Mehmet, Doherty, Dearbhla, Cooke, Niamh, Terraube, Virginie, Chion, Alain, Amin, Aamir, Hulshof, Anne-Marije, Baci, Bogdan, Byrne, Ciara, Aburawi, Hanan E., Lillicrap, David, O’Donnell, James S.

“…von Willebrand factor (VWF)-R1205H variant (Vicenza) results in markedly enhanced VWF clearance in humans that has been shown to be largely…”
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