Search Results - "Özata, M."

The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility by Wu, Pei-Hsuan, Fu, Yu, Cecchini, Katharine, Özata, Deniz M., Arif, Amena, Yu, Tianxiong, Colpan, Cansu, Gainetdinov, Ildar, Weng, Zhiping, Zamore, Phillip D.

“…Pachytene PIWI-interacting RNAs (piRNAs), which comprise >80% of small RNAs in the adult mouse testis, have been proposed to bind and regulate target RNAs like…”
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Long first exons and epigenetic marks distinguish conserved pachytene piRNA clusters from other mammalian genes by Yu, Tianxiong, Fan, Kaili, Özata, Deniz M., Zhang, Gen, Fu, Yu, Theurkauf, William E., Zamore, Phillip D., Weng, Zhiping

“…In the male germ cells of placental mammals, 26–30-nt-long PIWI-interacting RNAs (piRNAs) emerge when spermatocytes enter the pachytene phase of meiosis. In…”
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Dietary suppression of MHC class II expression in intestinal epithelial cells enhances intestinal tumorigenesis by Beyaz, Semir, Chung, Charlie, Mou, Haiwei, Bauer-Rowe, Khristian E., Xifaras, Michael E., Ergin, Ilgin, Dohnalova, Lenka, Biton, Moshe, Shekhar, Karthik, Eskiocak, Onur, Papciak, Katherine, Ozler, Kadir, Almeqdadi, Mohammad, Yueh, Brian, Fein, Miriam, Annamalai, Damodaran, Valle-Encinas, Eider, Erdemir, Aysegul, Dogum, Karoline, Shah, Vyom, Alici-Garipcan, Aybuke, Meyer, Hannah V., Özata, Deniz M., Elinav, Eran, Kucukural, Alper, Kumar, Pawan, McAleer, Jeremy P., Fox, James G., Thaiss, Christoph A., Regev, Aviv, Roper, Jatin, Orkin, Stuart H., Yilmaz, Ömer H.

“…Little is known about how interactions of diet, intestinal stem cells (ISCs), and immune cells affect early-stage intestinal tumorigenesis. We show that a…”
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The role of microRNA deregulation in the pathogenesis of adrenocortical carcinoma by Özata, Deniz M, Caramuta, Stefano, Velázquez-Fernández, David, Akçakaya, Pinar, Xie, Hong, Höög, Anders, Zedenius, Jan, Bäckdahl, Martin, Larsson, Catharina, Lui, Weng-Onn

“…Adrenocortical carcinoma (ACC) is an aggressive tumor showing frequent metastatic spread and poor survival. Although recent genome-wide studies of ACC have…”
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Evolutionarily conserved pachytene piRNA loci are highly divergent among modern humans by Özata, Deniz M., Yu, Tianxiong, Mou, Haiwei, Gainetdinov, Ildar, Colpan, Cansu, Cecchini, Katharine, Kaymaz, Yasin, Wu, Pei-Hsuan, Fan, Kaili, Kucukural, Alper, Weng, Zhiping, Zamore, Phillip D.

“…In the fetal mouse testis, PIWI-interacting RNAs (piRNAs) guide PIWI proteins to silence transposons but, after birth, most post-pubertal pachytene piRNAs map…”
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Role of microRNAs and microRNA machinery in the pathogenesis of diffuse large B-cell lymphoma by Caramuta, S, Lee, L, Özata, D M, Akçakaya, P, Georgii-Hemming, P, Xie, H, Amini, R-M, Lawrie, C H, Enblad, G, Larsson, C, Berglund, M, Lui, W-O

“…Deregulation of microRNA (miRNA) expression has been documented in diffuse large B-cell lymphoma (DLBCL). However, the impact of miRNAs and their machinery in…”
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MicroRNA expression patterns associated with hyperfunctioning and non-hyperfunctioning phenotypes in adrenocortical adenomas by Velázquez-Fernández, David, Caramuta, Stefano, Özata, Deniz M, Lu, Ming, Höög, Anders, Bäckdahl, Martin, Larsson, Catharina, Lui, Weng-Onn, Zedenius, Jan

“…BackgroundThe adrenocortical adenoma (ACA) entity includes aldosterone-producing adenoma (APA), cortisol-producing adenoma (CPA), and non-hyperfunctioning…”
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DEBrowser: interactive differential expression analysis and visualization tool for count data by Kucukural, Alper, Yukselen, Onur, Ozata, Deniz M, Moore, Melissa J, Garber, Manuel

“…Sequencing data has become a standard measure of diverse cellular activities. For example, gene expression is accurately measured by RNA sequencing (RNA-Seq)…”
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The MYBL1/TCFL5 transcription network: two collaborative factors with central role in male meiosis by Säflund, Martin, Özata, Deniz M

“…Male gametogenesis, spermatogenesis, is a stepwise developmental process to generate mature sperm. The most intricate process of spermatogenesis is meiosis…”
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The effect of testosterone replacement treatment on immunological features of patients with Klinefelter's syndrome by Koçar, I. H., Yesilova, Z., Özata, M., Turan, M., Sengül, A., Özdemir, I. Ç.

“…Although the effects of androgen deficiency in the immune system have long been appreciated, little is known about the immunological features of patients with…”
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GTSF1 accelerates target RNA cleavage by PIWI-clade Argonaute proteins by Arif, Amena, Bailey, Shannon, Izumi, Natsuko, Anzelon, Todd A., Ozata, Deniz M., Andersson, Cecilia, Gainetdinov, Ildar, MacRae, Ian J., Tomari, Yukihide, Zamore, Phillip D.

“…Argonaute proteins use nucleic acid guides to find and bind specific DNA or RNA target sequences. Argonaute proteins have diverse biological functions and many…”
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Terminal modification, sequence, length, and PIWI-protein identity determine piRNA stability by Gainetdinov, Ildar, Colpan, Cansu, Cecchini, Katharine, Arif, Amena, Jouravleva, Karina, Albosta, Paul, Vega-Badillo, Joel, Lee, Yongjin, Özata, Deniz M., Zamore, Phillip D.

“…In animals, PIWI-interacting RNAs (piRNAs) silence transposons, fight viral infections, and regulate gene expression. piRNA biogenesis concludes with 3′…”
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A-MYB/TCFL5 regulatory architecture ensures the production of pachytene piRNAs in placental mammals by Yu, Tianxiong, Biasini, Adriano, Cecchini, Katharine, Saflund, Martin, Mou, Haiwei, Arif, Amena, Eghbali, Atiyeh, de Rooij, Dirk, Weng, Zhiping, Zamore, Phillip D, Ozata, Deniz M

“…In male mice, the transcription factor A MYB initiates the transcription of pachytene piRNA genes during meiosis. Here, we report that A MYB activates the…”
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miR-185 and miR-133b deregulation is associated with overall survival and metastasis in colorectal cancer by AKCAKAYA, Pinar, EKELUND, Susanne, KOLOSENKO, Iryna, CARAMUTA, Stefano, ÖZATA, Deniz M, HONG XIE, LINDFORSS, Ulrik, OLIVECRONA, Hans, LUI, Weng-Onn

“…Colorectal cancer (CRC) is one of the most common and deadly forms of cancer. Despite improved treatment modalities, post-operative recurrence and metastasis…”
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The transcription factor TCFL5 responds to A-MYB to elaborate the male meiotic program in mice by Cecchini, Katharine, Biasini, Adriano, Yu, Tianxiong, Säflund, Martin, Mou, Haiwei, Arif, Amena, Eghbali, Atiyeh, Colpan, Cansu, Gainetdinov, Ildar, de Rooij, Dirk G, Weng, Zhiping, Zamore, Phillip D, Özata, Deniz M

“…In brief The testis-specific transcription factor, TCFL5, expressed in pachytene spermatocytes regulates the meiotic gene expression program in collaboration…”
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Clinical and functional impact of TARBP2 over-expression in adrenocortical carcinoma by Caramuta, Stefano, Lee, Linkiat, Özata, Deniz M, Akçakaya, Pinar, Xie, Hong, Höög, Anders, Zedenius, Jan, Bäckdahl, Martin, Larsson, Catharina, Lui, Weng-Onn

“…Deregulation of microRNA (miRNA) expression in adrenocortical carcinomas (ACCs) has been documented to have diagnostic, prognostic, as well as functional…”
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Hypermigration of macrophages through the concerted action of GRA effectors on NF-κB/p38 signaling and host chromatin accessibility potentiates Toxoplasma dissemination by Ten Hoeve, Arne L, Rodriguez, Matias E, Säflund, Martin, Michel, Valentine, Magimel, Lucas, Ripoll, Albert, Yu, Tianxiong, Hakimi, Mohamed-Ali, Saeij, Jeroen P J, Ozata, Deniz M, Barragan, Antonio

“…Mononuclear phagocytes facilitate the dissemination of the obligate intracellular parasite . Here, we report how a set of secreted parasite effector proteins…”
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Human leptin deficiency caused by a missense mutation : Multiple endocrine defects, decreased sympathetic tone, and immune system dysfunction indicate new targets for leptin action, greater central than peripheral resistance to the effects of leptin, and spontaneous correction of leptin-mediated defects by OZATA, M, OZDEMIR, I. C, LICINIO, J

“…We have previously demonstrated that genetically based leptin deficiency due to a missense leptin gene mutation in a highly consanguineous extended Turkish…”
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CRISPR/Cas9-mediated genome editing induces exon skipping by alternative splicing or exon deletion by Mou, Haiwei, Smith, Jordan L, Peng, Lingtao, Yin, Hao, Moore, Jill, Zhang, Xiao-Ou, Song, Chun-Qing, Sheel, Ankur, Wu, Qiongqiong, Ozata, Deniz M, Li, Yingxiang, Anderson, Daniel G, Emerson, Charles P, Sontheimer, Erik J, Moore, Melissa J, Weng, Zhiping, Xue, Wen

“…CRISPR is widely used to disrupt gene function by inducing small insertions and deletions. Here, we show that some single-guide RNAs (sgRNAs) can induce exon…”
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CRISPR-SONIC: targeted somatic oncogene knock-in enables rapid in vivo cancer modeling by Mou, Haiwei, Ozata, Deniz M, Smith, Jordan L, Sheel, Ankur, Kwan, Suet-Yan, Hough, Soren, Kucukural, Alper, Kennedy, Zachary, Cao, Yueying, Xue, Wen

“…CRISPR/Cas9 has revolutionized cancer mouse models. Although loss-of-function genetics by CRISPR/Cas9 is well-established, generating gain-of-function alleles…”
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