Search Results - "Önnerfjord, Patrik"

The minor collagens in articular cartilage by Luo, Yunyun, Sinkeviciute, Dovile, He, Yi, Karsdal, Morten, Henrotin, Yves, Mobasheri, Ali, Önnerfjord, Patrik, Bay-Jensen, Anne

“…Articular cartilage is a connective tissue consisting of a specialized extracellular matrix （ECM） that dominates the bulk of its wet and dry weight. Type Ⅱ…”
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Interleukin-1 receptor antagonist (IL-1Ra) is more effective in suppressing cytokine-induced catabolism in cartilage-synovium co-culture than in cartilage monoculture by Mehta, Shikhar, Akhtar, Sumayyah, Porter, Ryan M, Önnerfjord, Patrik, Bajpayee, Ambika G

“…Most in vitro studies of potential osteoarthritis (OA) therapies have used cartilage monocultures, even though synovium is a key player in mediating joint…”
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Proteomics Profiling of Human Synovial Fluid Suggests Increased Protein Interplay in Early-Osteoarthritis (OA) That Is Lost in Late-Stage OA by Ali, Neserin, Turkiewicz, Aleksandra, Hughes, Velocity, Folkesson, Elin, Tjörnstand, Jon, Neuman, Paul, Önnerfjord, Patrik, Englund, Martin

“…The underlying molecular mechanisms in osteoarthritis (OA) development are largely unknown. This study explores the proteome and the pairwise interplay of…”
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Novel missense ACAN gene variants linked to familial osteochondritis dissecans cluster in the C-terminal globular domain of aggrecan by Stattin, Eva-Lena, Lindblom, Karin, Struglics, André, Önnerfjord, Patrik, Goldblatt, Jack, Dixit, Abhijit, Sarkar, Ajoy, Randell, Tabitha, Suri, Mohnish, Raggio, Cathleen, Davis, Jessica, Carter, Erin, Aspberg, Anders

“…The cartilage aggrecan proteoglycan is crucial for both skeletal growth and articular cartilage function. A number of aggrecan ( ACAN) gene variants have been…”
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Identification and quantification of degradome components in human synovial fluid reveals an increased proteolytic activity in knee osteoarthritis patients vs controls by Rydén, Martin, Turkiewicz, Aleksandra, Önnerfjord, Patrik, Tjörnstrand, Jon, Englund, Martin, Ali, Neserin

“…Synovial fluid (SF) may contain cleavage products of proteolytic activities. Our aim was to characterize the degradome through analysis of proteolytic activity…”
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Elucidating the Molecular Composition of Cartilage by Proteomics by Hsueh, Ming-Feng, Khabut, Areej, Kjellström, Sven, Önnerfjord, Patrik, Kraus, Virginia Byers

“…Articular cartilage consists of chondrocytes and two major components, a collagen-rich framework and highly abundant proteoglycans. Most prior studies defining…”
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Quantitative Proteomic Analysis of Eight Cartilaginous Tissues Reveals Characteristic Differences as well as Similarities between Subgroups by Önnerfjord, Patrik, Khabut, Areej, Reinholt, Finn P., Svensson, Olle, Heinegård, Dick

“…Human synovial joints display a characteristic anatomic distribution of arthritis, e.g. rheumatoid arthritis primarily affects the metacarpophalangeal and…”
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Targeted proteomics of hip articular cartilage in OA and fracture patients by Hosseininia, Shahrzad, Önnerfjord, Patrik, Dahlberg, Leif E.

“…ABSTRACT Osteoarthritis (OA) is a common chronic disease, causing joint pain and reduced physical function. OA progresses slowly over a period of several…”
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Exploring the Early Molecular Pathogenesis of Osteoarthritis Using Differential Network Analysis of Human Synovial Fluid by Rydén, Martin, Sjögren, Amanda, Önnerfjord, Patrik, Turkiewicz, Aleksandra, Tjörnstrand, Jon, Englund, Martin, Ali, Neserin

“…The molecular mechanisms that drive the onset and development of osteoarthritis (OA) remain largely unknown. In this exploratory study, we used a proteomic…”
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A human meniscus explant model for studying early events in osteoarthritis development by proteomics by Rydén, Martin, Lindblom, Karin, Yifter-Lindgren, Aida, Turkiewicz, Aleksandra, Aspberg, Anders, Tillgren, Viveka, Englund, Martin, Önnerfjord, Patrik

“…Degenerative meniscus lesions have been associated with both osteoarthritis etiology and its progression. We, therefore, sought to establish a human meniscus…”
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Quantitative proteomics analysis of cartilage response to mechanical injury and cytokine treatment by Wang, Yang, Li, Yang, Khabut, Areej, Chubinskaya, Susan, Grodzinsky, Alan J., Önnerfjord, Patrik

“…Mechanical damage at the time of joint injury and the ensuing inflammatory response associated with elevated levels of pro-inflammatory cytokines in the…”
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The Tyrosine Sulfate Domain of Fibromodulin Binds Collagen and Enhances Fibril Formation by Tillgren, Viveka, Mörgelin, Matthias, Önnerfjord, Patrik, Kalamajski, Sebastian, Aspberg, Anders

“…Small leucine-rich proteoglycans interact with other extracellular matrix proteins and are important regulators of matrix assembly. Fibromodulin has a key role…”
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Development of a Cartilage Oligomeric Matrix Protein Neo-Epitope Assay for the Detection of Intra-Thecal Tendon Disease by Smith, Roger, Önnerfjord, Patrik, Holmgren, Kristin, di Grado, Shacko, Dudhia, Jayesh

“…The diagnosis of tendon injury relies on clinical signs and diagnostic imaging but imaging is subjective and does not always correlate with clinical signs. A…”
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Differential protein expression in human knee articular cartilage and medial meniscus using two different proteomic methods: a pilot analysis by Folkesson, Elin, Turkiewicz, Aleksandra, Englund, Martin, Önnerfjord, Patrik

“…Proteomics is an emerging field in the study of joint disease. Our two aims with this pilot analysis were to compare healthy human knee articular cartilage…”
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Prevalence and classification of meniscal calcifications in the human knee by Shakya, Bijay Ratna, Karjalainen, Ville-Pauli, Hellberg, Iida, Finnilä, Mikko A.J., Elkhouly, Khaled, Sjögren, Amanda, Turkiewicz, Aleksandra, Önnerfjord, Patrik, Hughes, Velocity, Tjörnstrand, Jon, Englund, Martin, Saarakkala, Simo

“…To investigate the occurrence of meniscal calcifications in individuals with and without knee osteoarthritis (OA). Additionally, we aim to identify the…”
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A novel biomarker of MMP-cleaved prolargin is elevated in patients with psoriatic arthritis by Sinkeviciute, Dovile, Skovlund Groen, Solveig, Sun, Shu, Manon-Jensen, Tina, Aspberg, Anders, Önnerfjord, Patrik, Bay-Jensen, Anne-Christine, Kristensen, Salome, Holm Nielsen, Signe

“…Psoriatic arthritis (PsA) is a chronic musculoskeletal inflammatory disease found in up to 30% of psoriasis patients. Prolargin—an extracellular matrix (ECM)…”
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Mining the Proteome Associated with Rheumatic and Autoimmune Diseases by Ruiz-Romero, Cristina, Lam, Maggie P. Y, Nilsson, Peter, Önnerfjord, Patrik, Utz, Paul J, Van Eyk, Jennifer E, Venkatraman, Vidya, Fert-Bober, Justyna, Watt, Fiona E, Blanco, Francisco J

“…A steady increase in the incidence of osteoarthritis and other rheumatic diseases has been observed in recent decades, including autoimmune conditions such as…”
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Proteomic characterization of the normal human medial meniscus body using data‐independent acquisition mass spectrometry by Folkesson, Elin, Turkiewicz, Aleksandra, Rydén, Martin, Hughes, Harini Velocity, Ali, Neserin, Tjörnstrand, Jon, Önnerfjord, Patrik, Englund, Martin

“…Recent research suggests an important role of the meniscus in the development of knee osteoarthritis. We, therefore, aimed to analyze the proteome of the…”
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Biomarkers and proteomic analysis of osteoarthritis by Hsueh, Ming-Feng, Önnerfjord, Patrik, Kraus, Virginia Byers

“…Our friend and colleague, Dr. Dick Heinegård, contributed greatly to the understanding of joint tissue biochemistry, the discovery and validation of…”
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Manufacturing of Human Tissues as off‐the‐Shelf Grafts Programmed to Induce Regeneration by Pigeot, Sébastien, Klein, Thibaut, Gullotta, Fabiana, Dupard, Steven J., Garcia Garcia, Alejandro, García‐García, Andres, Prithiviraj, Sujeethkumar, Lorenzo, Pilar, Filippi, Miriam, Jaquiery, Claude, Kouba, Loraine, Asnaghi, M. Adelaide, Raina, Deepak Bushan, Dasen, Boris, Isaksson, Hanna, Önnerfjord, Patrik, Tägil, Magnus, Bondanza, Attilio, Martin, Ivan, Bourgine, Paul E.

“…Design criteria for tissue‐engineered materials in regenerative medicine include robust biological effectiveness, off‐the‐shelf availability, and scalable…”
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