Effect of Platelet-Rich Fibrin on Peripheral Nerve Regeneration

This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses. Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), whic...

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Bibliographic Details
Published in:	The Journal of craniofacial surgery Vol. 27; no. 7; pp. 1759 - 1764
Main Authors:	Şenses, Fatma, Önder, Mustafa E, Koçyiğit, Ismail D, Kul, Oğuz, Aydin, Gülümser, Inal, Elem, Atil, Fethi, Tekin, Umut
Format:	Journal Article
Language:	English
Published:	United States 01-10-2016
Subjects:	Animals Blood Platelets Dentistry Disease Models, Animal Female Fibrin Nerve Regeneration - physiology Peripheral Nerve Injuries - physiopathology Peripheral Nerve Injuries - therapy Rats Rats, Wistar Recovery of Function Sciatic Nerve - injuries
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Summary:	This study aimed to evaluate the effect of platelet-rich fibrin (PRF) on peripheral nerve regeneration on the sciatic nerve of rats by using functional, histopathologic, and electrophysiologic analyses. Thirty female Wistar rats were divided randomly into 3 experimental groups. In group 1 (G1), which was the control group, the sciatic nerve was transected and sutured (n = 10). In group 2 (G2), the sciatic nerve was transected, sutured, and then covered with PRF as a membrane (n = 10). In group 3 (G3), the sciatic nerve was transected, sutured by leaving a 5-mm gap, and then covered by PRF as a nerve guide (n = 10). Functional, histopathologic, and electrophysiologic analyses were performed. The total histopathologic semiquantitative score was significantly higher in G1 compared to G2 and G3 (P < 0.05). Myelin thickness and capillaries were significantly lower in G3 compared to G1 (P < 0.05). There was no statistically significant difference between the groups with regard to the functional and electrophysiologic results. The study results suggest that PRF decreases functional recovery in sciatic nerve injury. Further studies are required to determine the efficacy of PRF on peripheral nerve regeneration.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1049-2275 1536-3732
DOI:	10.1097/SCS.0000000000003066