Search Results - "Öllinger, Karin"

Restoration of lysosomal function after damage is accompanied by recycling of lysosomal membrane proteins by Eriksson, Ida, Wäster, Petra, Öllinger, Karin

“…Lysosomes are central organelles for cellular degradation and energy homeostasis. In addition, lysosomal membrane permeabilization (LMP) and subsequent release…”
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The lysosome: from waste bag to potential therapeutic target by Appelqvist, Hanna, Wäster, Petra, Kågedal, Katarina, Öllinger, Karin

“…Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior. They are central for degradation and recycling of macromolecules…”
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Regulation of apoptosis-associated lysosomal membrane permeabilization by Johansson, Ann-Charlotte, Appelqvist, Hanna, Nilsson, Cathrine, Kågedal, Katarina, Roberg, Karin, Öllinger, Karin

“…Lysosomal membrane permeabilization (LMP) occurs in response to a large variety of cell death stimuli causing release of cathepsins from the lysosomal lumen…”
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Lysosomotropic agents: impact on lysosomal membrane permeabilization and cell death by Villamil Giraldo, Ana M, Appelqvist, Hanna, Ederth, Thomas, Öllinger, Karin

“…Lysosomes are acidic organelles essential for degradation, signalling and cell homoeostasis. In addition, they play a key role in cell death. Permeabilization…”
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Apoptosis in idiopathic inflammatory myopathies with partial invasion; a role for CD8+ cytotoxic T cells? by Danielsson, Olof, Häggqvist, Bo, Gröntoft, Liv, Öllinger, Karin, Ernerudh, Jan

“…Polymyositis and inclusion body myositis are idiopathic inflammatory myopathies, with a pathology characterized by partial invasion of non-necrotic muscle…”
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Resveratrol induces apoptosis and inhibits angiogenesis in human breast cancer xenografts in vivo by Garvin, Stina, Öllinger, Karin, Dabrosin, Charlotta

“…Resveratrol, a polyphenol found in grapes and wine, is considered a potential cancer chemopreventive agent. Resveratrol has been shown to induce transcription…”
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Redox-Dependent Translocation of p53 to Mitochondria or Nucleus in Human Melanocytes after UVA- and UVB-Induced Apoptosis by Wäster, Petra K., Öllinger, Karin M.

“…The p53 protein is an important transcription factor and tumor suppressor that is induced in response to many forms of cellular stress. UVA irradiation of…”
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Evaluation of tubulin β-3 and 5 hydroxy-methyl cytosine as diagnostic and prognostic markers in malignant melanoma by Katarzyna, Lundmark, Kyriakos, Orfanidis, Linda, Vainikka, Ingrid, Synnerstad, Petra, Wäster, Karin, Öllinger

“…Tubulin β-3 staining pattern and staining intensity of 5-hydroxymethyl cytosine (5-hmC) are potential diagnostic and prognostic markers in melanocytic lesions…”
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Amyloid-β induced membrane damage instigates tunneling nanotube-like conduits by p21-activated kinase dependent actin remodulation by Dilna, Aysha, Deepak, K V, Damodaran, Nandini, Kielkopf, Claudia S, Kagedal, Katarina, Ollinger, Karin, Nath, Sangeeta

“…Alzheimer's disease (AD) pathology progresses gradually via anatomically connected brain regions. Direct transfer of amyloid-β oligomers (oAβ) between…”
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Attenuation of the Lysosomal Death Pathway by Lysosomal Cholesterol Accumulation by Appelqvist, Hanna, Nilsson, Cathrine, Garner, Brett, Brown, Andrew J, Kågedal, Katarina, Öllinger, Karin

“…In the past decade, lysosomal membrane permeabilization (LMP) has emerged as a significant component of cell death signaling. The mechanisms by which lysosomal…”
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Interactions of the Lysosomotropic Detergent O-Methyl-Serine Dodecylamide Hydrochloride (MSDH) with Lipid Bilayer Membranes-Implications for Cell Toxicity by Villamil Giraldo, Ana-Maria, Eriksson, Ida, Wennmalm, Stefan, Fyrner, Timmy, Ederth, Thomas, Öllinger, Karin

“…O-methyl-serine dodecylamine hydrochloride (MSDH) is a detergent that accumulates selectively in lysosomes, a so-called lysosomotropic detergent, with…”
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UVA/B-Induced Apoptosis in Human Melanocytes Involves Translocation of Cathepsins and Bcl-2 Family Members by Bivik, Cecilia A., Larsson, Petra K., Kågedal, Katarina M., Rosdahl, Inger K., Öllinger, Karin M.

“…We demonstrate UVA/B to induce apoptosis in human melanocytes through the mitochondrial pathway, displaying cytochrome c release, caspase-3 activation, and…”
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Analysis of Lysosomal pH by Flow Cytometry Using FITC-Dextran Loaded Cells by Eriksson, Ida, Öllinger, Karin, Appelqvist, Hanna

“…The acidic environment of the lysosomal lumen provides an optimal milieu for the acid hydrolases and is also essential for fusion/fission of endo-lysosomal…”
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Real-Time Monitoring of Lysosomal Membrane Permeabilization Using Acridine Orange by Eriksson, Ida, Vainikka, Linda, Persson, Hans Lennart, Öllinger, Karin

“…Loss of lysosomal membrane integrity results in leakage of lysosomal hydrolases to the cytosol which might harm cell function and induce cell death…”
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Sensitivity to lysosome-dependent cell death is directly regulated by lysosomal cholesterol content by Appelqvist, Hanna, Sandin, Linnea, Björnström, Karin, Saftig, Paul, Garner, Brett, Ollinger, Karin, Kågedal, Katarina

“…Alterations in lipid homeostasis are implicated in several neurodegenerative diseases, although the mechanisms responsible are poorly understood. We evaluated…”
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The lysosomal protease cathepsin D mediates apoptosis induced by oxidative stress by Kågedal, Katarina, Johansson, Uno, Öllinger, Karin

“…ABSTRACT It has been suggested that lysosomes and the lysosomal proteases cathepsin D and B act as proapoptotic mediators of apoptosis, in addition to…”
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Inhibition of Cathepsin D Prevents Free-Radical-Induced Apoptosis in Rat Cardiomyocytes by Ollinger, K

“…Apoptosis was inhibited in rat cardiomyocytes pretreated with the aspartic protease inhibitor pepstatin A and subsequently exposed to naphthazarin…”
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Melanoma growth and progression after ultraviolet a irradiation: impact of lysosomal exocytosis and cathepsin proteases by Eding, Cecilia Bivik, Domert, Jakob, Wäster, Petra, Jerhammar, Fredrik, Rosdahl, Inger, Öllinger, Karin

“…Ultraviolet (UV) irradiation is a risk factor for development of malignant melanoma. UVA-induced lysosomal exocytosis and subsequent cell growth enhancement…”
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Lysosomal release of Cathepsin D precedes relocation of Cytochrome C and loss of mitochondrial transmembrane potential during apoptosis induced by oxidative stress by Roberg, Karin, Johansson, Uno, Öllinger, Karin

“…Apoptosis was induced in human foreskin fibroblasts by the redox-cycling quinone naphthazarin (5,8-dihydroxy-1,4-naphthoquinone). Most of the cells displayed…”
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Intrinsic differences in cisplatin sensitivity of head and neck cancer cell lines: Correlation to lysosomal pH by Nilsson, Cathrine, Roberg, Karin, Grafström, Roland C., Öllinger, Karin

“…Background Cisplatin treatment is beneficial for approximately 20% of patients with head and neck squamous cell carcinoma (HNSCC). Tools to predict the…”
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