Early Childhood Overweight and Asthma and Allergic Sensitization at 8 Years of Age

Early Childhood Overweight and Asthma and Allergic Sensitization at 8 Years of Age

Our aim was to examine the associations between high BMI and changes in BMI status during the first 7 years of life and asthma and allergic sensitization at age 8 years. A birth cohort of newborn infants was followed for 8 years. Repeated parental questionnaires provided information on environmental...

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Bibliographic Details
Published in:Pediatrics (Evanston) Vol. 129; no. 1; pp. 70 - 76
Main Authors: ÖHMAN MAGNUSSON, Jessica, KULL, Inger, MAI, Xiao-Mei, WICKMAN, Magnus, BERGSTROM, Anna
Format: Journal Article
Language:English
Published: Elk Grove Village, IL American Academy of Pediatrics 2012
Subjects:
Allergy in children
Asthma
Asthma - complications
Asthma - immunology
Asthma in children
Biological and medical sciences
Body Mass Index
Causes of
Child
Child health
Child, Preschool
Childhood asthma
Childhood obesity
Children
Chronic obstructive pulmonary disease, asthma
Correlation analysis
Female
Follow-Up Studies
General aspects
Health aspects
Humans
Immunoglobulin E - blood
Infant
Male
Measurement
Medical sciences
Medicin och hälsovetenskap
Metabolic diseases
Newborn babies
Obesity
Obesity in children
Overweight - complications
Pediatric allergy
Pediatrics
Pneumology
Respiratory Hypersensitivity - complications
Risk assessment
Risk Factors
United States
Human
Immunopathology
Lung disease
Allergy
Pediatrics
Respiratory disease
Body weight
Corporal biometry
Asthma
Overweight
Body mass index
Cohort study
allergic sensitization
Bronchus disease
Sensitization
Obstructive pulmonary disease
Child
Age
Public health
BMI
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Summary:Our aim was to examine the associations between high BMI and changes in BMI status during the first 7 years of life and asthma and allergic sensitization at age 8 years. A birth cohort of newborn infants was followed for 8 years. Repeated parental questionnaires provided information on environmental exposures and health outcomes. Information on height and weight during childhood was retrieved from preschool and school health care records. The analyses included the 2075 children for whom information was available on weight and height, as well as on asthma, at age 8 years. A high BMI (≥85th percentile) at age 1, 4, and/or 7 years was associated with an increased risk of asthma at age 8 years. However, no significant association was observed among children with high BMI at age 12 and/or 18 months (early age) or at age 4 years who developed a normal BMI by age 7 years. The risk was increased among children with high BMI at age 7 years, regardless of their earlier weight. Moreover, we observed an increased risk of sensitization to inhalant allergens among children with high BMI at age 7 years. Our study indicates that high BMI during the first 4 years does not increase the risk of asthma at school age among children who have developed a normal weight by age 7 years. However, high BMI at age 7 years is associated with an increased risk of asthma and sensitization to inhalant allergens.
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ISSN:0031-4005
1098-4275
1098-4275
DOI:10.1542/peds.2010-2953