Ginkgo biloba (EGb 761) usage attenuates testicular injury induced by testicular ischemia/reperfusion in rats

Introduction We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Materials and methods Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) f...

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Published in:	International urology and nephrology Vol. 40; no. 3; pp. 685 - 690
Main Authors:	Akgül, Turgay, Ayyildiz, Ali, Nuholu, Baris, Karagüzel, Ersagun, Öüs, Elmas, Yamurdur, Hatice, Üstün, Hüseyin, Germiyanolu, Cankon
Format:	Journal Article
Language:	English
Published:	Dordrecht Springer Netherlands 01-09-2008 Springer Nature B.V
Subjects:	Analysis of Variance Animals Male Malondialdehyde - metabolism Medicine Medicine & Public Health Nephrology Nitrates - metabolism Nitrites - metabolism Original Paper Plant Extracts - pharmacology Rats Rats, Wistar Reperfusion Injury - drug therapy Spermatic Cord Torsion - drug therapy Statistics, Nonparametric Testis - blood supply Testis - drug effects Urology Ginkgo biloba Testicular torsion Testis Ischemia reperfusion Nitric oxide
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Summary:	Introduction We investigated the effect of ginkgo biloba on testicular ischemia-reperfusion (IR) injury. Materials and methods Thirty-two Wistar Albino rats were randomly assigned into four groups. Torsion/detorsion (T/D) performed to the rats in group 1, group 2 received ginkgo biloba (50 mg/day) for a month before T/D, group 3 received only gingko biloba (50 mg/day) for a month and group 4 was defined as sham group. After 1 month the testes were removed. Results Mean testicular malondialdehyde, nitrate and nitrite levels were significantly increased in group 1 compared to groups 2, 3 and 4 ( P < 0.05). The rats in group 3 provided basal histological appearance. In group 1, edema, congestion and hemorrhage between seminiferous tubules were predominant. In group 2, histopathologic features were markedly less than group 1. Conclusions Malondialdehyde, nitrate and nitrite levels were increased after unilateral testicular torsion. EGb 761 has a protective effect on testicular injury induced by IR.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	0301-1623 1573-2584
DOI:	10.1007/s11255-007-9296-5