Search Results - "Ó’Fágáin, Ciarán"

Peptide synthesis by recombinant Fasciola hepatica cathepsin L1 by Ruth, Deborah M., McMahon, Gillian, Ó'Fágáin, Ciarán

“…Synthesis of the tripeptide Z-Phe-Arg-SerNH 2 has been accomplished by a recombinant cysteine protease, cathepsin L1 from liver fluke ( Fasciola hepatica),…”
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Antibody stability: A key to performance - Analysis, influences and improvement by Ma, Hui, Ó’Fágáin, Ciarán, O’Kennedy, Richard

“…An antibody’s stability greatly influences its performance (i.e. its specificity and affinity). Thus, stability is a major issue for researchers and…”
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Protein Stability: Enhancement and Measurement by Ó'Fágáin, Ciarán

“…This article defines protein stability, emphasizes its importance and surveys the field of protein stabilization, with summary reference to a selection of…”
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Corrigendum to “Chemical modification and immobilisation of laccase from Trametes hirsuta and from Myceliophtora thermophila” by Forde, Jessica, Tully, Elizabeth, Vakurov, Alex, Gibson, Tim D., Millner, Paul, Ó’Fágáin, Ciarán

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Enzyme stabilization—recent experimental progress by Ó’Fágáin, Ciarán

“…This article surveys the enzyme stabilization literature since 1997, focusing on protein engineering and chemical modification. Within protein engineering,…”
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Generation, selection and modification of anti-cardiac troponin I antibodies with high specificity and affinity by Ma, Hui, Cassedy, Arabelle, Ó'Fágáin, Ciarán, O'Kennedy, Richard

“…Current diagnosis of acute myocardial infarction involves quantification of circulating cTn levels. This work endeavoured to generate and enhance recombinant…”
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Storage and Lyophilization of Pure Proteins by Ó'Fágáin, Ciarán, Colliton, Keith

“…This article outlines empirical procedures for the storage of pure proteins with preservation of high levels of biological activity. It describes simple and…”
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Unravelling enhancement of antibody fragment stability – Role of format structure and cysteine modification by Ma, Hui, Ó'Fágáin, Ciarán, O'Kennedy, Richard

“…Antibody-based diagnostics and therapeutics have huge commercial value. However, applications of antibodies are often limited by instability, particularly for…”
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Gel-Filtration Chromatography by Ó'Fágáin, Ciarán, Cummins, Philip M, O'Connor, Brendan F

“…Gel-filtration chromatography is a versatile method that permits the effective separation of biological molecules in high yield. This article describes the…”
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Horseradish and soybean peroxidases: comparable tools for alternative niches? by Ryan, Barry J., Carolan, Neil, Ó’Fágáin, Ciarán

“…Horseradish and soybean peroxidases (HRP and SBP, respectively) are useful biotechnological tools. HRP is often termed the classical plant heme peroxidase and…”
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former annotated human pseudogene dihydrofolate reductase-like 1 (DHFRL1) is expressed and functional by McEntee, Gráinne, Minguzzi, Stefano, O’Brien, Kirsty, Ben Larbi, Nadia, Loscher, Christine, Ó’Fágáin, Ciarán, Parle-McDermott, Anne

“…Human dihydrofolate reductase (DHFR) was previously thought to be the only enzyme capable of the reduction of dihydrofolate to tetrahydrofolate; an essential…”
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Chemical modification and immobilisation of laccase from Trametes hirsuta and from Myceliophthora thermophila by Forde, Jessica, Tully, Elizabeth, Vakurov, Alex, Gibson, Tim D., Millner, Paul, Ó’Fágáin, Ciarán

“…Laccase from two different source organisms, Myceliophthora thermophila and Trametes hirsuta, were subjected to chemical modification in solution by (i) two…”
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Storage and lyophilisation of pure proteins by O'Fágáin, Ciarán

“…This article outlines empirical procedures for the storage of pure proteins with preservation of high levels of biological activity. It describes simple and…”
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Chemical modification and immobilisation of lipase B from Candida antarctica onto mesoporous silicates by Forde, Jessica, Vakurov, Alex, Gibson, Tim D., Millner, Paul, Whelehan, Mícheál, Marison, Ian W., Ó’Fágáin, Ciarán

“…The chemical modification and immobilisation of lipase B from Candida antarctica (CalB) onto three different types of mesoporous silicate (MPS) were…”
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Engineering protein stability by O'Fágáin, Ciarán

“…This article defines protein stability, emphasizes its importance and surveys some notable recent publications (2004-2008) in the field of protein…”
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Effects of single mutations on the stability of horseradish peroxidase to hydrogen peroxide by Ryan, Barry J., Ó'Fágáin, Ciarán

“…Horseradish peroxidase (HRP) is a commonly used enzyme in many biotechnological fields. Improvement of HRP stability would further increase its potential…”
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The phylogeny of the mammalian heme peroxidases and the evolution of their diverse functions by Loughran, Noeleen B, O'Connor, Brendan, O'Fágáin, Ciarán, O'Connell, Mary J

“…The mammalian heme peroxidases (MHPs) are a medically important group of enzymes. Included in this group are myeloperoxidase, eosinophil peroxidase,…”
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Functional consequence of positive selection revealed through rational mutagenesis of human myeloperoxidase by Loughran, Noeleen B, Hinde, Sara, McCormick-Hill, Sally, Leidal, Kevin G, Bloomberg, Sarah, Loughran, Sinéad T, O'Connor, Brendan, O'Fágáin, Ciarán, Nauseef, William M, O'Connell, Mary J

“…Myeloperoxidase (MPO) is a member of the mammalian heme peroxidase (MHP) multigene family. Whereas all MHPs oxidize specific halides to generate the…”
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Arginine-to-lysine substitutions influence recombinant horseradish peroxidase stability and immobilisation effectiveness by Ryan, Barry J, O'Fágáin, Ciarán

“…Horseradish Peroxidase (HRP) plays important roles in many biotechnological fields, including diagnostics, biosensors and biocatalysis. Often, it is used in…”
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Covalent Attachment of Ferrocene to Soybean Peroxidase Glycans:  Electron Transfer Mediation to Redox Enzymes by Carolan, Neil, Forster, Robert J, Ó'Fágáin, Ciarán

“…The electrochemical properties of native soybean peroxidase (SBP) and of SBP modified with covalently attached ferrocene electron-transfer mediators within…”
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