Search Results - "Ísola, José"

Combining shallow and deep geophysical information: the Yehuin–Chepelmut Fault Zone in the Magallanes fold and thrust belt (Tierra del Fuego, Argentina) by Lozano, Jorge G., Tassone, Alejandro, Bran, Donaldo M., Onnis, Luciano, Lodolo, Emanuele, Menichetti, Marco, Cerredo, María E., Esteban, Federico, Ormazabal, Juan P., Ísola, José, Baradello, Luca, Vilas, Juan F.

“…The outer Fuegian fold and thrust belt is the deformed sector of the Austral-Magallanes Basin, which underwent a contractional phase since the Late Cretaceous…”
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Glacial-related morphology and sedimentary setting of a high-latitude lacustrine basin: The Lago Chepelmut (Tierra del Fuego, Argentina) by Lozano, Jorge G., Tassone, Alejandro, Bran, Donaldo M., Lodolo, Emanuele, Menichetti, Marco, Cerredo, María E., Esteban, Federico, Ormazabal, Juan P., Ísola, José, Baradello, Luca, Vilas, Juan F.

“…Lago Chepelmut is a relatively small lake in size, of ellipsoidal shape, located in the outer fold-and-thrust belt of the Fuegian Andes (southernmost South…”
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Cellular hallmarks of aging emerge in the ovary prior to primordial follicle depletion by Ansere, Victor A., Ali-Mondal, Samim, Sathiaseelan, Roshini, Garcia, Driele N., Isola, José V.V., Henseb, Jéssica D., Saccon, Tatiana D., Ocañas, Sarah R., Tooley, Kyla B., Stout, Michael B., Schneider, Augusto, Freeman, Willard M.

“…•Ovarian primordial follicle depletion with aging occurs concomitantly with increased markers of cellular senescence.•Age-related ovarian transcriptomic…”
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17α-estradiol, a lifespan-extending compound, attenuates liver fibrosis by modulating collagen turnover rates in male mice by Ali Mondal, Samim, Sathiaseelan, Roshini, Mann, Shivani N, Kamal, Maria, Luo, Wenyi, Saccon, Tatiana D, Isola, José V V, Peelor, 3rd, Frederick F, Li, Tiangang, Freeman, Willard M, Miller, Benjamin F, Stout, Michael B

“…Estrogen signaling is protective against chronic liver diseases, although men and a subset of women are contraindicated for chronic treatment with…”
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MASLD does not affect fertility and senolytics fail to prevent MASLD progression in male mice by Hense, Jessica D., Garcia, Driele N., Zanini, Bianka M., Barreto, Mariana M., Perreira, Giulia C., Isola, José V. V., de Brito, Camila, Fornalik, Michal, Mondal, Samim A., Ávila, Bianca M., Oliveira, Thais L., Rice, Heather C., Lacy, Charles I., Vaucher, Rodrigo A., Mason, Jeffrey B., Masternak, Michal M., Stout, Michael B., Schneider, Augusto

“…Senescent cells have been linked to the pathogenesis of metabolic dysfunction-associated steatotic liver disease (MASLD). However, the effectiveness of…”
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The Interconnections Between Somatic and Ovarian Aging in Murine Models by Schneider, Augusto, Saccon, Tatiana D, Garcia, Driele N, Zanini, Bianka M, Isola, José V V, Hense, Jéssica D, Alvarado-Rincón, Joao A, Cavalcante, Marcelo B, Mason, Jeffrey B, Stout, Michael B, Bartke, Andrzej, Masternak, Michal M

“…Abstract The mammalian female is born with a limited ovarian reserve of primordial follicles. These primordial follicles are slowly activated throughout the…”
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A single-cell atlas of the aging mouse ovary by Isola, José V V, Ocañas, Sarah R, Hubbart, Chase R, Ko, Sunghwan, Mondal, Samim Ali, Hense, Jessica D, Carter, Hannah N C, Schneider, Augusto, Kovats, Susan, Alberola-Ila, José, Freeman, Willard M, Stout, Michael B

“…Ovarian aging leads to diminished fertility, dysregulated endocrine signaling and increased chronic disease burden. These effects begin to emerge long before…”
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Mild calorie restriction, but not 17α-estradiol, extends ovarian reserve and fertility in female mice by Isola, José V.V., Zanini, Bianka M., Hense, Jessica D., Alvarado-Rincón, Joao A., Garcia, Driele N., Pereira, Giulia C., Vieira, Arnaldo D., Oliveira, Thais L., Collares, Tiago, Gasperin, Bernardo G., Stout, Michael B., Schneider, Augusto

“…Calorie restriction (CR) (25–40%) is the most commonly studied strategy for curtailing age-related disease and has also been found to extend reproductive…”
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17α-Estradiol promotes ovarian aging in growth hormone receptor knockout mice, but not wild-type littermates by Isola, José V.V., Zanini, Bianka M., Sidhom, Silvana, Kopchick, John J., Bartke, Andrzej, Masternak, Michal M., Stout, Michael B., Schneider, Augusto

“…Growth hormone receptor knockout mice (GHRKO) have reduced body size and increased insulin sensitivity. These mice are known for having extended lifespan,…”
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Cell-Specific Paired Interrogation of the Mouse Ovarian Epigenome and Transcriptome by Ocañas, Sarah R, Isola, José V V, Saccon, Tatiana D, Pham, Kevin D, Chucair-Elliott, Ana J, Schneider, Augusto, Freeman, Willard M, Stout, Michael B

“…Assessing cell-type-specific epigenomic and transcriptomic changes are key to understanding ovarian aging. To this end, the optimization of the translating…”
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17α-estradiol does not adversely affect sperm parameters or fertility in male mice: implications for reproduction-longevity trade-offs by Isola, José V. V., Veiga, Gabriel B., de Brito, Camila R. C., Alvarado-Rincón, Joao A., Garcia, Driele N., Zanini, Bianka M., Hense, Jéssica D., Vieira, Arnaldo D., Garratt, Michael, Gasperin, Bernardo G., Schneider, Augusto, Stout, Michael B.

“…17α-estradiol (17α-E2) is referred to as a nonfeminizing estrogen that was recently found to extend healthspan and lifespan in male, but not female, mice…”
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The role of cellular senescence in ovarian aging by Hense, Jéssica D., Isola, José V. V., Garcia, Driele N., Magalhães, Larissa S., Masternak, Michal M., Stout, Michael B., Schneider, Augusto

“…This review explores the relationship between ovarian aging and senescent cell accumulation, as well as the efficacy of senolytics to improve reproductive…”
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Reproductive Ageing: Inflammation, immune cells, and cellular senescence in the aging ovary by Isola, José V V, Hense, Jessica D, Osório, César A P, Biswas, Subhasri, Alberola-Ila, José, Ocañas, Sarah R, Schneider, Augusto, Stout, Michael B

“…Recent reports suggest a relationship between ovarian inflammation and functional declines, although it remains unresolved if ovarian inflammation is the cause…”
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Effects of calorie, protein, and branched chain amino acid restriction on ovarian aging in mice by Veiga, Gabriel B., Zanini, Bianka M., Garcia, Driele Neske, Hense, Jéssica D., Barreto, Mariana M., Isola, José V.V., Mondadori, Rafael G., Masternak, Michal M., Stout, Michael B., Schneider, Augusto

“…Calorie restriction (CR) is an intervention that promotes longevity and preserves the ovarian reserve. Some studies have observed that the positive impacts of…”
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Dasatinib and quercetin increase testosterone and sperm concentration in mice by Garcia, Driele N, Hense, Jéssica D, Zanini, Bianka M, Isola, José V V, Pradiee, Jorgea, Prosczek, Juliane B, Alvarado-Rincón, Joao A, Mondadori, Rafael G, Mason, Jeffrey B, Brieño-Enríquez, Miguel A, Barros, Carlos C, Stout, Michael B, Masternak, Michal M, Schneider, Augusto

“…Cellular senescence is a defense mechanism to arrest proliferation of damaged cells. The number of senescent cells increases with age in different tissues and…”
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Senolytic treatment reverses obesity-mediated senescent cell accumulation in the ovary by Hense, Jéssica D., Garcia, Driele N., Isola, José V., Alvarado-Rincón, Joao A., Zanini, Bianka M., Prosczek, Juliane B., Stout, Michael B., Mason, Jeffrey B., Walsh, Patrick T., Brieño-Enríquez, Miguel A., Schadock, Ines, Barros, Carlos C., Masternak, Michal M., Schneider, Augusto

“…Senescent cells are in a cell cycle arrest state and accumulate with aging and obesity, contributing to a chronic inflammatory state. Treatment with senolytic…”
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Thermoregulatory response of black or red lactating Holstein cows in the hot and cold season in southern Brazil by Lazzari, Jéssica, Isola, José Victor Vieira, Szambelan, Vanessa Lambrecht, Menegazzi, Gabriel, Busanello, Marcos, Rovani, Monique Tomazele, Sarubbi, Juliana, Schmitt, Eduardo, Ferreira, Rogerio, Gonçalves, Paulo Bayard Dias, Gasperin, Bernardo Garziera, Mondadori, Rafael Gianella

“…Dairy cows in pasture-based systems are more susceptible to heat stress. Holstein cows have the black or red phenotypes, the latter having lower absorbance of…”
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Intrafollicular paraoxonase 1 activity and the steroidogenic potential of the first post‐partum dominant follicle in dairy cows by Isola, José Victor Vieira, Velasco Acosta, Diego Andres, Bespalhok Jacometo, Carolina, Rincón, Joao Alveiro Alvarado, Silveira, Pedro Augusto Silva, Corrêa, Marcio Nunes, Schneider, Augusto

“…Cows experiencing high levels of inflammation and specific metabolic conditions tend to have slower follicular growth and lower serum and follicular…”
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Educational academics and intellectuals in the democratic reconstruction of Argentina: Discussions around a modern scientific program by Isola, Nicolás José

“…In 1983, at the very end of the dictatorial period in Argentina, the reconstitution of the spaces in which knowledge was produced in education reopened…”
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Chromosomal and gonadal factors regulate microglial sex effects in the aging brain by Ocañas, Sarah R., Ansere, Victor A., Kellogg, Collyn M., Isola, Jose V.V., Chucair-Elliott, Ana J., Freeman, Willard M.

“…Biological sex contributes to phenotypic sex effects through genetic (sex chromosomal) and hormonal (gonadal) mechanisms. There are profound sex differences in…”
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