Search Results - "Çolak, Dilek"

Schizophrenia is defined by cell-specific neuropathology and multiple neurodevelopmental mechanisms in patient-derived cerebral organoids by Notaras, Michael, Lodhi, Aiman, Dündar, Friederike, Collier, Paul, Sayles, Nicole M., Tilgner, Hagen, Greening, David, Colak, Dilek

“…Due to an inability to ethically access developing human brain tissue as well as identify prospective cases, early-arising neurodevelopmental and cell-specific…”
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The proteomic architecture of schizophrenia iPSC-derived cerebral organoids reveals alterations in GWAS and neuronal development factors by Notaras, Michael, Lodhi, Aiman, Fang, Haoyun, Greening, David, Colak, Dilek

“…Schizophrenia (Scz) is a brain disorder that has a typical onset in early adulthood but otherwise maintains unknown disease origins. Unfortunately, little…”
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PD-L1 promotes OCT4 and Nanog expression in breast cancer stem cells by sustaining PI3K/AKT pathway activation by Almozyan, Sheema, Colak, Dilek, Mansour, Fatmah, Alaiya, Ayodele, Al-Harazi, Olfat, Qattan, Amal, Al-Mohanna, Falah, Al-Alwan, Monther, Ghebeh, Hazem

“…The expression of PD-L1 in breast cancer is associated with estrogen receptor negativity, chemoresistance and epithelial-to-mesenchymal transition (EMT), all…”
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Neurodevelopmental signatures of narcotic and neuropsychiatric risk factors in 3D human-derived forebrain organoids by Notaras, Michael, Lodhi, Aiman, Barrio-Alonso, Estibaliz, Foord, Careen, Rodrick, Tori, Jones, Drew, Fang, Haoyun, Greening, David, Colak, Dilek

“…It is widely accepted that narcotic use during pregnancy and specific environmental factors (e.g., maternal immune activation and chronic stress) may increase…”
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Bidirectional crosstalk between PD-L1 expression and epithelial to mesenchymal transition: significance in claudin-low breast cancer cells by Alsuliman, Abdullah, Colak, Dilek, Al-Harazi, Olfat, Fitwi, Hanaa, Tulbah, Asma, Al-Tweigeri, Taher, Al-Alwan, Monther, Ghebeh, Hazem

“…The T-cell inhibitory molecule PD-L1 (B7-H1, CD274) is expressed on tumor cells of a subset of breast cancer patients. However, the mechanism that regulates…”
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Promoter-Bound Trinucleotide Repeat mRNA Drives Epigenetic Silencing in Fragile X Syndrome by Colak, Dilek, Zaninovic, Nikica, Cohen, Michael S., Rosenwaks, Zev, Yang, Wang-Yong, Gerhardt, Jeannine, Disney, Matthew D., Jaffrey, Samie R.

“…Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X syndrome, the most common genetic form of mental retardation, a CGG…”
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UPF2 leads to degradation of dendritically targeted mRNAs to regulate synaptic plasticity and cognitive function by Notaras, Michael, Allen, Megan, Longo, Francesco, Volk, Nicole, Toth, Miklos, Li Jeon, Noo, Klann, Eric, Colak, Dilek

“…Synaptic plasticity requires a tight control of mRNA levels in dendrites. RNA translation and degradation pathways have been recently linked to…”
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Regulation of Axon Guidance by Compartmentalized Nonsense-Mediated mRNA Decay by Colak, Dilek, Ji, Sheng-Jian, Porse, Bo T., Jaffrey, Samie R.

“…Growth cones enable axons to navigate toward their targets by responding to extracellular signaling molecules. Growth-cone responses are mediated in part by…”
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RNA-Seq transcriptome profiling in three liver regeneration models in rats: comparative analysis of partial hepatectomy, ALLPS, and PVL by Colak, Dilek, Al-Harazi, Olfat, Mustafa, Osama M., Meng, Fanwei, Assiri, Abdullah M., Dhar, Dipok K., Broering, Dieter C.

“…The liver is a unique organ that has a phenomenal capacity to regenerate after injury. Different surgical procedures, including partial hepatectomy (PH),…”
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Prenatal Drugs and Their Effects on the Developing Brain: Insights From Three-Dimensional Human Organoids by Stankovic, Isidora N, Colak, Dilek

“…Decades of research have unequivocally demonstrated that fetal exposure to both recreational and prescription drugs negatively impacts the developing brain…”
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Reactive Glia in the Injured Brain Acquire Stem Cell Properties in Response to Sonic Hedgehog by Sirko, Swetlana, Behrendt, Gwendolyn, Johansson, Pia Annette, Tripathi, Pratibha, Costa, Marcos Romualdo, Bek, Sarah, Heinrich, Christophe, Tiedt, Steffen, Colak, Dilek, Dichgans, Martin, Fischer, Isabel Rebekka, Plesnila, Nikolaus, Staufenbiel, Matthias, Haass, Christian, Snapyan, Marina, Saghatelyan, Armen, Tsai, Li-Huei, Fischer, André, Grobe, Kay, Dimou, Leda, Götz, Magdalena

“…As a result of brain injury, astrocytes become activated and start to proliferate in the vicinity of the injury site. Recently, we had demonstrated that these…”
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Treatment of retinitis pigmentosa due to MERTK mutations by ocular subretinal injection of adeno-associated virus gene vector: results of a phase I trial by Ghazi, Nicola G., Abboud, Emad B., Nowilaty, Sawsan R., Alkuraya, Hisham, Alhommadi, Abdulrahman, Cai, Huimin, Hou, Rui, Deng, Wen-Tao, Boye, Sanford L., Almaghamsi, Abdulrahman, Al Saikhan, Fahad, Al-Dhibi, Hassan, Birch, David, Chung, Christopher, Colak, Dilek, LaVail, Matthew M., Vollrath, Douglas, Erger, Kirsten, Wang, Wenqiu, Conlon, Thomas, Zhang, Kang, Hauswirth, William, Alkuraya, Fowzan S.

“…MERTK is an essential component of the signaling network that controls phagocytosis in retinal pigment epithelium (RPE), the loss of which results in…”
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Origin and progeny of reactive gliosis: A source of multipotent cells in the injured brain by Buffo, Annalisa, Rite, Inmaculada, Tripathi, Pratibha, Lepier, Alexandra, Colak, Dilek, Horn, Ana-Paula, Mori, Tetsuji, Götz, Magdalena

“…Reactive gliosis is the universal reaction to brain injury, but the precise origin and subsequent fate of the glial cells reacting to injury are unknown…”
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Astrocytes derived from ASD individuals alter behavior and destabilize neuronal activity through aberrant Ca2+ signaling by Allen, Megan, Huang, Ben S., Notaras, Michael J., Lodhi, Aiman, Barrio-Alonso, Estibaliz, Lituma, Pablo J., Wolujewicz, Paul, Witztum, Jonathan, Longo, Francesco, Chen, Maoshan, Greening, David W., Klann, Eric, Ross, M. Elizabeth, Liston, Conor, Colak, Dilek

“…The cellular mechanisms of autism spectrum disorder (ASD) are poorly understood. Cumulative evidence suggests that abnormal synapse function underlies many…”
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Signaling through BMPR-IA Regulates Quiescence and Long-Term Activity of Neural Stem Cells in the Adult Hippocampus by Mira, Helena, Andreu, Zoraida, Suh, Hoonkyo, Lie, D. Chichung, Jessberger, Sebastian, Consiglio, Antonella, San Emeterio, Juana, Hortigüela, Rafael, Marqués-Torrejón, María Ángeles, Nakashima, Kinichi, Colak, Dilek, Götz, Magdalena, Fariñas, Isabel, Gage, Fred H.

“…Neural stem cells (NSCs) in the adult hippocampus divide infrequently, and the molecules that modulate their quiescence are largely unknown. Here, we show that…”
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Transcriptomic data analysis coupled with copy number aberrations reveals a blood-based 17-gene signature for diagnosis and prognosis of patients with colorectal cancer by Kaya, Ibrahim H, Al-Harazi, Olfat, Colak, Dilek

“…Colorectal cancer (CRC) is the third most common cancer and third leading cause of cancer-associated deaths worldwide. Diagnosing CRC patients reliably at an…”
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A Network-Based Methodology to Identify Subnetwork Markers for Diagnosis and Prognosis of Colorectal Cancer by Al-Harazi, Olfat, Kaya, Ibrahim H., El Allali, Achraf, Colak, Dilek

“…The development of reliable methods for identification of robust biomarkers for complex diseases is critical for disease diagnosis and prognosis efforts…”
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The DNA Replication Program Is Altered at the FMR1 Locus in Fragile X Embryonic Stem Cells by Gerhardt, Jeannine, Tomishima, Mark J., Zaninovic, Nikica, Colak, Dilek, Yan, Zi, Zhan, Qiansheng, Rosenwaks, Zev, Jaffrey, Samie R., Schildkraut, Carl L.

“…Fragile X syndrome (FXS) is caused by a CGG repeat expansion in the FMR1 gene that appears to occur during oogenesis and during early embryogenesis. One model…”
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THE ROLES OF ENDOTHELIAL CELL PATHOLOGY IN SCHIZOPHRENIA IPSC-DERIVED MODELS by Stankovic, Isidora, Colak, Dilek, Notaras, Michael, Wolujewicz, Paul

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Coupled local translation and degradation regulate growth cone collapse by Deglincerti, Alessia, Liu, Yaobin, Colak, Dilek, Hengst, Ulrich, Xu, Guoqiang, Jaffrey, Samie R.

“…Local translation mediates axonal responses to Semaphorin3A (Sema3A) and other guidance cues. However, only a subset of the axonal proteome is locally…”
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