Search Results - "Çiftçi, Gülşen Akalin"

New chromanone derivatives containing thiazoles: Synthesis and antitumor activity evaluation on A549 lung cancer cell line by Yurttaş, Leyla, Temel, Halide Edip, Aksoy, Mehmet Onur, Bülbül, Emre Fatih, Çiftçi, Gülşen Akalin

“…Novel 2‐[2‐(chroman‐4‐ylidene)hydrazinyl]‐4/5‐substituted thiazole derivatives (2a–i) were synthesized and investigated for their anticancer activity…”
Get full text

Synthesis, density functional theory calculation, molecular docking studies, and evaluation of novel 5‐nitrothiophene derivatives for anticancer activity by Nuha, Demokrat, Evren, Asaf E., Çiyanci, Zennure Ş., Temel, Halide E., Akalin Çiftçi, Gülşen, Yurttaş, Leyla

“…Within the scope of this study, new 2‐{2‐[(5‐nitrothiophen‐2‐yl)methylene]hydrazinyl}thiazole derivatives (2a–j) were synthesized and investigated for their…”
Get full text

Evaluation of new sulfathiazole derivatives as antiproliferative agents by Yurttaş, Leyla, Akalin Çiftçi, Gülşen, Temel, Halide Edip

Get full text

New Thiazoline-Tetralin Derivatives and Biological Activity Evaluation by Turan-Zitouni, Gülhan, Yurttaş, Leyla, Tabbi, Aouatef, Akalın Çiftçi, Gülşen, Temel, Halide Edip, Kaplancıklı, Zafer Asım

“…In this study, novel '-(3-cyclohexyl/phenyl-4-(substituted phenyl)thiazole-2(3 )-ylidene)-2-[(5,6,7,8-tetrahydronaphthalen-2-yl)oxy]acetohydrazide ( - )…”
Get full text

Comprehensive Study on Thiadiazole-Based Anticancer Agents Inducing Cell Cycle Arrest and Apoptosis/Necrosis Through Suppression of Akt Activity in Lung Adenocarcinoma and Glioma Cells by Akalin Çiftçi, Gülşen, Sever, Belgin, Altintop, Mehlika Dilek

“…Akt is considered as an attractive target for anticancer drug discovery and development and therefore extensive efforts have been devoted to the discovery of…”
Get full text

Cytotoxic, Antiproliferative and Apoptotic Effects of New Benzimidazole Derivatives on A549 Lung Carcinoma and C6 Glioma Cell Lines by Yurttas, Leyla, Demirayak, Seref, Ciftci, Gulsen Akalın

“…Benzimidazole ring is a versatile structure which has been extensively utilized in medicinal chemistry. Since we are working on 1,2-disubstutited…”
Get more information

Novel metabolic enzyme inhibitors designed through the molecular hybridization of thiazole and pyrazoline scaffolds by Sever, Belgin, Türkeş, Cüneyt, Altıntop, Mehlika D., Demir, Yeliz, Akalın Çiftçi, Gülşen, Beydemir, Şükrü

“…New hybrid thiazolyl–pyrazoline derivatives (4a–k) were obtained through a facile and versatile synthetic procedure, and their inhibitory effects on the human…”
Get full text

Synthesis, molecular docking, and molecular dynamic simulation studies of new 1,3,4-thiadiazole derivatives as potential apoptosis inducers in A549 lung cancer cell line by Yurttaş, Leyla, Evren, Asaf Evrim, AlChaib, Huda, Temel, Halide Edip, Akalin Çiftçi, Gülşen

“…1,3,4-Thiadiazoles are structures that are bioisosteres of 1,3,4-oxadiazole and pyrimidine ring, which are found in the structure of many drugs and anticancer…”
Get full text

Novel imidazo[2,1‐b]thiazole‐based anticancer agents as potential focal adhesion kinase inhibitors: Synthesis, in silico and in vitro evaluation by Başoğlu, Faika, Ulusoy‐Güzeldemirci, Nuray, Akalın‐Çiftçi, Gülşen, Çetinkaya, Serap, Ece, Abdulilah

“…The purpose of this study was to synthesize imidazo[2,1‐b]thiazole derivatives, characterize them with spectroscopical techniques and investigate for cytotoxic…”
Get full text

A new series of thiazole‐hydrazone hybrids for Akt‐targeted therapy of non‐small cell lung cancer by Orujova, Turana, Ece, Abdulilah, Akalın Çiftçi, Gülşen, Özdemir, Ahmet, Altıntop, Mehlika D.

“…In an attempt to identify potent antitumor agents for the fight against non‐small cell lung cancer, new thiazolyl hydrazones (2a–n) were synthesized and…”
Get full text

Escin reduces cell proliferation and induces apoptosis on glioma and lung adenocarcinoma cell lines by Çiftçi, Gülşen Akalin, Işcan, Arzu, Kutlu, Mehtap

“…Aesculus hippocastanum (the horse chestnut) seed extract has a wide variety of biochemical and pharmacological effects including anti-inflammatory,…”
Get full text

A new series of 2,4-thiazolidinediones endowed with potent aldose reductase inhibitory activity by Sever, Belgin, Altıntop, Mehlika Dilek, Demir, Yeliz, Türkeş, Cüneyt, Özbaş, Kaan, Çiftçi, Gülşen Akalın, Beydemir, Şükrü, Özdemir, Ahmet

“…In an effort to identify potent aldose reductase (AR) inhibitors, 5-(arylidene)thiazolidine-2,4-diones ( ), which were prepared by the solvent-free reaction of…”
Get full text

In Vitro and In Silico Evaluation of Anticancer Activity of New Indole-Based 1,3,4-Oxadiazoles as EGFR and COX-2 Inhibitors by Sever, Belgin, Altıntop, Mehlika Dilek, Özdemir, Ahmet, Akalın Çiftçi, Gülşen, Ellakwa, Doha E, Tateishi, Hiroshi, Radwan, Mohamed O, Ibrahim, Mahmoud A A, Otsuka, Masami, Fujita, Mikako, Ciftci, Halil I, Ali, Taha F S

“…Epidermal growth factor receptor (EGFR) and cyclooxygenase-2 (COX-2) are crucial targetable enzymes in cancer management. Therefore, herein, new 2-[(5-((1…”
Get full text

Design, Synthesis, and Evaluation of a New Series of Thiazole-Based Anticancer Agents as Potent Akt Inhibitors by Altıntop, Mehlika Dilek, Sever, Belgin, Akalın Çiftçi, Gülşen, Özdemir, Ahmet

“…In an attempt to develop potent anticancer agents targeting Akt, new thiazole derivatives ( ⁻ ) were synthesized and investigated for their cytotoxic effects…”
Get full text

Synthesis and biological evaluation of thiazoline derivatives as new antimicrobial and anticancer agents by Altıntop, Mehlika Dilek, Kaplancıklı, Zafer Asım, Çiftçi, Gülşen Akalın, Demirel, Rasime

“…N′-(3,4-Diarylthiazol-2(3H)-ylidene)-2-(arylthio)acetohydrazides were synthesized and evaluated for their antimicrobial activity and cytotoxicity against…”
Get full text

A new series of benzoxazole‐based SIRT1 modulators for targeted therapy of non‐small‐cell lung cancer by Sever, Belgin, Akalın Çiftçi, Gülşen, Altıntop, Mehlika Dilek

“…In an attempt to identify potential anticancer agents for non‐small‐cell lung cancer (NSCLC) targeting sirtuin 1 (SIRT1), the synthesis of a new series of…”
Get full text

Synthesis and Evaluation of New Benzodioxole- Based Thiosemicarbazone Derivatives as Potential Antitumor Agents by Altıntop, Mehlika Dilek, Temel, Halide Edip, Sever, Belgin, Akalın Çiftçi, Gülşen, Kaplancıklı, Zafer Asım

“…New benzodioxole-based thiosemicarbazone derivatives were synthesized and evaluated for their cytotoxic effects on A549 human lung adenocarcinoma, C6 rat…”
Get full text

Synthesis and evaluation of new indole-based chalcones as potential antiinflammatory agents by Özdemir, Ahmet, Altıntop, Mehlika Dilek, Turan-Zitouni, Gülhan, Çiftçi, Gülşen Akalın, Ertorun, İpek, Alataş, Özkan, Kaplancıklı, Zafer Asım

“…In the present work, new indole-based chalcone derivatives were obtained via the reaction of…”
Get full text

Pharmacophore‐Based Modeling, Synthesis, and Biological Evaluation of Novel Quinazoline/Quinoline Derivatives: Discovery of EGFR Inhibitors with Low Nanomolar Activity by Evren, Asaf Evrim, Sağlik Özkan, Begüm Nurpelin, Akalin‐Çiftçi, Gülşen, Yurttaş, Leyla

“…The main aim of this study is to obtain novel molecules that are more selective on cancer cells compared to healthy cells. For this purpose, four hit molecules…”
Get full text

Discovery of Small Molecule COX-1 and Akt Inhibitors as Anti-NSCLC Agents Endowed with Anti-Inflammatory Action by Altıntop, Mehlika Dilek, Akalın Çiftçi, Gülşen, Yılmaz Savaş, Nalan, Ertorun, İpek, Can, Betül, Sever, Belgin, Temel, Halide Edip, Alataş, Özkan, Özdemir, Ahmet

“…Targeted therapies have come into prominence in the ongoing battle against non-small cell lung cancer (NSCLC) because of the shortcomings of traditional…”
Get full text