Autoimmune hepatitis and primary biliary cholangitis overlap syndrome after mRNA COVID-19 vaccination

The overlap syndrome indicates an association between autoimmune hepatitis (AIH) and sclerosis cholangitis or primary biliary cholangitis (PBC). We report a case of a 32-year-old patient who experienced overlap syndrome ten days after receiving the first dose of the mRNA Coronavirus disease-2019 (CO...

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Bibliographic Details
Published in:	Gülhane tıp dergisi Vol. 65; no. 3; pp. 141 - 144
Main Authors:	Çetinkaya, Nadir Süleyman, Cengiz, Mustafa, Gül Aydın, Emine
Format:	Journal Article
Language:	English
Published:	Ankara Gulhane Medical Journal 01-09-2023 Galenos Publishing House
Subjects:	Abdomen autoimmune hepatitis Bile ducts Biopsy Cholangitis Conflicts of interest covid-19 vaccine COVID-19 vaccines Edema Gastroenterology Health sciences Hepatitis Hepatology Immunoglobulins Laboratories Liver cirrhosis mrna vaccine overlap syndrome Patients Phosphatase primary biliary cholangitis Severe acute respiratory syndrome coronavirus 2 Substance abuse treatment Ankara Turkey Turkey
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Summary:	The overlap syndrome indicates an association between autoimmune hepatitis (AIH) and sclerosis cholangitis or primary biliary cholangitis (PBC). We report a case of a 32-year-old patient who experienced overlap syndrome ten days after receiving the first dose of the mRNA Coronavirus disease-2019 (COVID-19) vaccine. Liver biopsy showed primarily AIH and “overlap syndrome” for PBC. Serum IgG was elevated, and ANA (1/100) and anti-mitochondrial antibody was positive. The patient’s treatment plan included prednisolone, ursodeoxycholic acid and azathioprine. Overlap syndrome related to the mRNA COVID-19 vaccines is a very rare entity. After the histopathological diagnosis of the patient, remission was achieved following treatment.
ISSN:	1302-0471 2146-8052
DOI:	10.4274/gulhane.galenos.2023.66376