Search Results - "Åkerström, Bo"

It's About Time: Time-Dependent Tissue Damage in the Adult Porcine Retina After Enucleation by Svare, Frida, Åkerström, Bo, Ghosh, Fredrik

“…The ex vivo large animal retina is extensively used in research ranging from discovery of disease mechanisms to future treatment paradigms. Due to limited…”
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Pregnant alpha-1-microglobulin (A1M) knockout mice exhibit features of kidney and placental damage, hemodynamic changes and intrauterine growth restriction by Aleksenko, Larysa, Åkerström, Bo, Hansson, Eva, Erlandsson, Lena, Hansson, Stefan R.

“…Alpha-1-microglobulin (A1M) is an antioxidant previously shown to be elevated in maternal blood during pregnancies complicated by preeclampsia and suggested to…”
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Editorial: Functional Profile of the Lipocalin Protein Family by Ganfornina, Maria Dolores, Åkerström, Bo, Sanchez, Diego

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Effects of Recombinant α1-Microglobulin on Early Proteomic Response in Risk Organs after Exposure to 177Lu-Octreotate by Ytterbrink, Charlotte, Shubbar, Emman, Parris, Toshima Z., Langen, Britta, Druid, Malin, Schüler, Emil, Strand, Sven-Erik, Åkerström, Bo, Gram, Magnus, Helou, Khalil, Forssell-Aronsson, Eva

“…Recombinant α1-microglobulin (A1M) is proposed as a protector during 177Lu-octreotate treatment of neuroendocrine tumors, which is currently limited by bone…”
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α1-Microglobulin Binds Illuminated Flavins and Has a Protective Effect Against Sublethal Riboflavin-Induced Damage in Retinal Epithelial Cells by Bergwik, Jesper, Åkerström, Bo

“…Riboflavin (vitamin B2) is an important constituent of the prosthetic groups flavin adenine dinucleotide (FAD) and flavin mononucleotide (FMN), which are…”
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Structure, Functions, and Physiological Roles of the Lipocalin α1-Microglobulin (A1M) by Bergwik, Jesper, Kristiansson, Amanda, Allhorn, Maria, Gram, Magnus, Åkerström, Bo

“…α 1 -microglobulin (A1M) is found in all vertebrates including humans. A1M was, together with retinol-binding protein and β-lactoglobulin, one of the three…”
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The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators by Gram, Magnus, Anderson, Ulrik Dolberg, Johansson, Maria E, Edström-Hägerwall, Anneli, Larsson, Irene, Jälmby, Maya, Hansson, Stefan R, Åkerström, Bo

“…Preeclampsia (PE) complicates 3-8% of all pregnancies and manifests clinically as hypertension and proteinuria in the second half of gestation. The…”
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Longitudinal changes in plasma hemopexin and alpha-1-microglobulin concentrations in women with and without clinical risk factors for pre-eclampsia by Murtoniemi, Katja, Kalapotharakos, Grigorios, Vahlberg, Tero, Räikkonen, Katri, Kajantie, Eero, Hämäläinen, Esa, Åkerström, Bo, Villa, Pia M, Hansson, Stefan R, Laivuori, Hannele

“…Recent studies have shown increased concentration of fetal hemoglobin (HbF) in pre-eclamptic women. Plasma hemopexin (Hpx) and alpha-1-microglobulin (A1M) are…”
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A1M Ameliorates Preeclampsia-Like Symptoms in Placenta and Kidney Induced by Cell-Free Fetal Hemoglobin in Rabbit by Nääv, Åsa, Erlandsson, Lena, Axelsson, Josefin, Larsson, Irene, Johansson, Martin, Wester-Rosenlöf, Lena, Mörgelin, Matthias, Casslén, Vera, Gram, Magnus, Åkerström, Bo, Hansson, Stefan R

“…Preeclampsia is one of the most serious pregnancy-related diseases and clinically manifests as hypertension and proteinuria after 20 gestational weeks. The…”
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Hemopexin and α1-microglobulin heme scavengers with differential involvement in preeclampsia and fetal growth restriction by Youssef, Lina, Erlandsson, Lena, Åkerström, Bo, Miranda, Jezid, Paules, Cristina, Crovetto, Francesca, Crispi, Fatima, Gratacos, Eduard, Hansson, Stefan R.

“…Hemopexin and α1-microglobulin act as scavengers to eliminate free heme-groups responsible for hemoglobin-induced oxidative stress. The present study evaluated…”
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Heme Induces Endoplasmic Reticulum Stress (HIER Stress) in Human Aortic Smooth Muscle Cells by Gáll, Tamás, Pethő, Dávid, Nagy, Annamária, Hendrik, Zoltán, Méhes, Gábor, Potor, László, Gram, Magnus, Åkerström, Bo, Smith, Ann, Nagy, Péter, Balla, György, Balla, József

“…Accumulation of damaged or misfolded proteins resulted from oxidative protein modification induces endoplasmic reticulum (ER) stress by activating the pathways…”
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Syncytiotrophoblast vesicles show altered micro-RNA and haemoglobin content after ex-vivo perfusion of placentas with haemoglobin to mimic preeclampsia by Cronqvist, Tina, Saljé, Karen, Familari, Mary, Guller, Seth, Schneider, Henning, Gardiner, Chris, Sargent, Ian L, Redman, Christopher W, Mörgelin, Matthias, Åkerström, Bo, Gram, Magnus, Hansson, Stefan R

“…Cell-free foetal haemoglobin (HbF) has been shown to play a role in the pathology of preeclampsia (PE). In the present study, we aimed to further characterize…”
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The heme and radical scavenger α1-microglobulin (A1M) confers early protection of the immature brain following preterm intraventricular hemorrhage by Romantsik, Olga, Agyemang, Alex Adusei, Sveinsdóttir, Snjolaug, Rutardóttir, Sigurbjörg, Holmqvist, Bo, Cinthio, Magnus, Mörgelin, Mattias, Gumus, Gulcin, Karlsson, Helena, Hansson, Stefan R., Åkerström, Bo, Ley, David, Gram, Magnus

“…Background Germinal matrix intraventricular hemorrhage (GM-IVH) is associated with cerebro-cerebellar damage in very preterm infants, leading to…”
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Heme-induced contractile dysfunction in Human cardiomyocytes caused by oxidant damage to thick filament proteins by Alvarado, Gerardo, Jeney, Viktória, Tóth, Attila, Csősz, Éva, Kalló, Gergő, Huynh, An T., Hajnal, Csaba, Kalász, Judit, Pásztor, Enikő T., Édes, István, Gram, Magnus, Akerström, Bo, Smith, Ann, Eaton, John W., Balla, György, Papp, Zoltán, Balla, József

“…Intracellular free heme predisposes to oxidant-mediated tissue damage. We hypothesized that free heme causes alterations in myocardial contractility via…”
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A1M, an extravascular tissue cleaning and housekeeping protein: a possible drug candidate by Magnus, Gram, Bo, Åkerström

“…Alpha-1-microglobulin (A1M) is a small protein found intra- and extracellularly in all tissues of vertebrates. The protein was discovered 40 years ago and its…”
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Binding of the human antioxidation protein α1-microglobulin (A1M) to heparin and heparan sulfate. Mapping of binding site, molecular and functional characterization, and co-localization in vivo and in vitro by Bergwik, Jesper, Kristiansson, Amanda, Larsson, Jörgen, Ekström, Simon, Åkerström, Bo, Allhorn, Maria

“…Heparin and heparan sulfate (HS) are linear sulfated disaccharide polymers. Heparin is found mainly in mast cells, while heparan sulfate is found in connective…”
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Fetal hemoglobin and α1 -microglobulin as first- and early second-trimester predictive biomarkers for preeclampsia by Anderson, Ulrik Dolberg, MD, Olsson, Magnus G., PhD, Rutardóttir, Sigurbjörg, MSc, Centlow, Magnus, PhD, Kristensen, Karl Heby, MD, PhD, Isberg, Per Erik, BSc, Thilaganathan, Baskaran, MD, PhD, Åkerström, Bo, PhD, Hansson, Stefan R., MD, PhD

“…Objective The aim of this study was to evaluate fetal hemoglobin (HbF) and α1 -microglobulin (A1M) in maternal serum as first-trimester biomarkers for…”
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Correction: The Human Endogenous Protection System against Cell-Free Hemoglobin and Heme Is Overwhelmed in Preeclampsia and Provides Potential Biomarkers and Clinical Indicators by Gram, Magnus, Anderson, Ulrik Dolberg, Johansson, Maria E, Edström-Hägerwall, Anneli, Larsson, Irene, Jälmby, Maya, Hansson, Stefan R, Åkerström, Bo

“…[This corrects the article DOI: 10.1371/journal.pone.0138111.]…”
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Ferryl Hemoglobin and Heme Induce A1-Microglobulin in Hemorrhaged Atherosclerotic Lesions with Inhibitory Function against Hemoglobin and Lipid Oxidation by Pethő, Dávid, Gáll, Tamás, Hendrik, Zoltán, Nagy, Annamária, Beke, Lívia, Gergely, Attila Péter, Méhes, Gábor, Tóth, Csaba, Gram, Magnus, Åkerström, Bo, Balla, György, Balla, József

“…Infiltration of red blood cells into atheromatous plaques and oxidation of hemoglobin (Hb) and lipoproteins are implicated in the pathogenesis of…”
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Redox properties of the lipocalin α1-microglobulin: Reduction of cytochrome c, hemoglobin, and free iron by Allhorn, Maria, Klapyta, Anna, Åkerström, Bo

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