Search Results - "Åkerblom, Malin"
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Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area
Published in Neuron (Cambridge, Mass.) (17-07-2019)“…Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of…”
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2
miRNAs in brain development
Published in Experimental cell research (01-02-2014)“…MicroRNAs (miRNAs) are small, non-coding RNAs that negatively regulate gene expression at the post-transcriptional level. In the brain, a large number of…”
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3
let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy
Published in The EMBO journal (15-05-2017)“…During adult neurogenesis, newly formed olfactory bulb (OB) interneurons migrate radially to integrate into specific layers of the OB. Despite the importance…”
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4
Identification and validation of novel engineered AAV capsid variants targeting human glia
Published in Frontiers in neuroscience (13-08-2024)“…Direct neural conversion of endogenous non-neuronal cells, such as resident glia, into therapeutic neurons has emerged as a promising strategy for brain…”
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MicroRNA-124 is a subventricular zone neuronal fate determinant
Published in The Journal of neuroscience (27-06-2012)“…New neurons are continuously generated from neural stem cells with astrocyte properties, which reside in close proximity to the ventricle in the postnatal and…”
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Distinct cognitive effects and underlying transcriptome changes upon inhibition of individual miRNAs in hippocampal neurons
Published in Scientific reports (27-01-2016)“…MicroRNAs (miRNA) are small, non-coding RNAs mediating post-transcriptional regulation of gene expression. miRNAs have recently been implicated in…”
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Visualization and genetic modification of resident brain microglia using lentiviral vectors regulated by microRNA-9
Published in Nature communications (2013)“…Functional studies of resident microglia require molecular tools for their genetic manipulation. Here we show that microRNA-9-regulated lentiviral vectors can…”
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Visualizing Arc protein dynamics and localization in the mammalian brain using AAV-mediated in situ gene labeling
Published in Frontiers in molecular neuroscience (15-06-2023)“…The activity-regulated cytoskeleton-associated (Arc) protein is essential for synaptic plasticity and memory formation. The Arc gene, which contains remnants…”
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microRNA-125 distinguishes developmentally generated and adult-born olfactory bulb interneurons
Published in Development (Cambridge) (01-04-2014)“…New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic…”
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Comprehensive analysis of microRNA expression in regionalized human neural progenitor cells reveals microRNA-10 as a caudalizing factor
Published in Development (Cambridge) (15-09-2015)“…MicroRNAs (miRNAs) have been implicated in regulating multiple processes during brain development in various species. However, the function of miRNAs in human…”
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Identification of the miRNA targetome in hippocampal neurons using RIP-seq
Published in Scientific reports (28-07-2015)“…MicroRNAs (miRNAs) are key players in the regulation of neuronal processes by targeting a large network of target messenger RNAs (mRNAs). However, the identity…”
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A novel two-factor monosynaptic TRIO tracing method for assessment of circuit integration of hESC-derived dopamine transplants
Published in Stem cell reports (11-01-2022)“…Transplantation in Parkinson's disease using human embryonic stem cell (hESC)-derived dopaminergic (DA) neurons is a promising future treatment option…”
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13
MicroRNAs as Neuronal Fate Determinants
Published in The Neuroscientist (01-06-2014)“…Since the discovery of short, regulatory microRNAs (miRNA) 20 years ago, the understanding of their impact on gene regulation has dramatically increased…”
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Book Review Journal Article -
14
TARGET-seq: Linking single-cell transcriptomics of human dopaminergic neurons with their target specificity
Published in Proceedings of the National Academy of Sciences - PNAS (19-11-2024)“…Dopaminergic (DA) neurons exhibit significant diversity characterized by differences in morphology, anatomical location, axonal projection pattern, and…”
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Functional Studies of microRNAs in Neural Stem Cells: Problems and Perspectives
Published in Frontiers in neuroscience (01-01-2012)“…In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of…”
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Thermoregulation via Temperature-Dependent PGD 2 Production in Mouse Preoptic Area
Published in Neuron (Cambridge, Mass.) (17-07-2019)Get full text
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17
Lineage tracing of stem cell-derived dopamine grafts in a Parkinson's model reveals shared origin of all graft-derived cells
Published in Science advances (18-10-2024)“…Stem cell therapies for Parkinson's disease are at an exciting time of development, and several clinical trials have recently been initiated. Human pluripotent…”
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18
Thermoregulation via Temperature-Dependent PGD 2 Production in Mouse Preoptic Area
Published in Neuron (Cambridge, Mass.) (17-07-2019)“…Body temperature control is essential for survival. In mammals, thermoregulation is mediated by the preoptic area of anterior hypothalamus (POA), with ∼30% of…”
Get full text
Journal Article -
19
Thermoregulation via Temperature-Dependent PGD2 Production in Mouse Preoptic Area
Published in Neuron (Cambridge, Mass.) (17-07-2019)Get full text
Journal Article -
20
microRNA distinguishes temporally different populations of olfactory bulb interneurons
Published in Neurogenesis (Philadelphia, Pa.) (01-01-2014)“…A central question in the field of adult neurogenesis is whether adult-born neurons in the olfactory bulb (OB) become similar to the developmentally generated…”
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