Search Results - "Åkerblom, H. K."

Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up by Akerblom, H K, Krischer, J, Virtanen, S M, Berseth, C, Becker, D, Dupré, J, Ilonen, J, Trucco, M, Savilahti, E, Koski, K, Pajakkala, E, Fransiscus, M, Lough, G, Bradley, B, Koski, M, Knip, M

“…Aims/hypothesis The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study was designed to establish whether weaning to a highly hydrolysed formula in…”
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Temporal changes in the frequencies of HLA genotypes in patients with Type 1 diabetes: indication of an increased environmental pressure? by HERMANN, R, KNIP, M, VEIJOLA, R, SIMELL, O, LAINE, A.-P, AKERBLOM, H. K, GROOP, P.-H, FORSBLOM, C, PETTERSSON-FERNHOLM, K, ILONEN, J

“…The incidence of Type 1 diabetes has increased 2.5 times during the time period from 1966 to 2000 in Finland-a general trend seen in almost all developed…”
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Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes : a pilot study by AKERBLOM, H. K, VIRTANEN, S. M, ILONEN, J, SAVILAHTI, E, VAARALA, O, REUNANEN, A, TERAMO, K, HÄMÄLÄINEN, A.-M, PARONEN, J

“…We aimed to assess the feasibility of a dietary intervention trial with weaning to hydrolysed formula in infants at increased risk of type 1 diabetes and to…”
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Prediction of type 1 diabetes among siblings of affected children and in the general population by SILJANDER, H. T, VEIJOLA, R, REIINANEN, A, VIRTANEN, S. M, AKERBLOM, H. K, KNIP, M

“…To compare the predictive characteristics of autoantibodies to GAD (GADA) and islet antigen 2 (IA-2A) for type 1 diabetes between siblings of affected children…”
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Feasibility and compliance in a nutritional primary prevention trial in infants at increased risk for type 1 diabetes by Virtanen, SM, Bärlund, S, Salonen, M, Savilahti, E, Reunanen, A, Paronen, J, Hämäläinen, A-M, Ilonen, J, Teramo, K, Erkkola, M, Ormisson, A, Einberg, Ü, Riikjärv, M-A, Ludvigsson, JG, Knip, M, Åkerblom, HK

“…Aim:  The international Trial to Reduce IDDM in the Genetically at Risk (TRIGR) was launched to determine whether weaning to a highly hydrolysed formula in…”
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The HLA-DR phenotype modulates the humoral immune response to enterovirus antigens by SADEHARJU, K, KNIP, M, HILTUNEN, M, AKERBLOM, H. K, HYÖTY, H

“…Enterovirus infections are among the environmental risk factors potentially contributing to the pathogenesis of Type 1 diabetes. The aim of this study was to…”
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Genetic Modification of Risk Assessment Based on Staging of Preclinical Type 1 Diabetes in Siblings of Affected Children by Mrena, S., Savola, K., Kulmala, P., Reijonen, H., Ilonen, J., Åkerblom, H. K., Knip, M.

“…We set out to study the association between human leukocyte antigen-defined genetic disease susceptibility and the stage of preclinical type 1 diabetes and…”
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Erratum to: The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up by Åkerblom, H. K.

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Natural course of preclinical type 1 diabetes in siblings of affected children by Mrena, S, Savola, K, Kulmala, P, Åkerblom, HK, Knip, M

“…Aim: To define the dynamics of preclinical type 1 diabetes in siblings of affected children and to characterize the siblings experiencing a progressive…”
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Pregnancy induces nonimmunoglobulin insulin‐binding activity in both maternal and cord blood serum by Ronkainen, M. S., Hämäläinen, A. ‐M., Koskela, P., Åkerblom, H. K., Knip, M.

“…To evaluate whether pregnancy has any effect on insulin antibody levels and to test the concordance between a conventional radioimmunoassay and a new…”
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Soluble adhesion molecules in pre-clinical Type 1 diabetes: a prospective study by TOIVONEN, A. M, KULMALA, P, SAVOLA, K, AKERBLOM, H. K, KNIP, M

“…This prospective case-control study aimed at evaluating the time course of serum concentrations of soluble adhesion molecules; intercellular adhesion…”
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Experience of severe hypoglycaemia may influence both patient's and physician's subsequent treatment policy of insulin-dependent diabetes mellitus by TUPOLA, S, RAJANTIE, J, AKERBLOM, H. K

“…Daily insulin doses and HbA1c were studied 0-3 months before and 2-6, 7-11, and 12-16 months after 48 consecutive episodes of severe hypoglycaemia (coma and/or…”
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Disease‐associated autoantibodies during pregnancy and at birth in families affected by type 1 diabetes by Hämäläinen, A.‐M., Savola, K., Kulmala, P. K., Koskela, P., Åkerblom, H. K., Knip, M.

“…We studied the pattern of type 1 diabetes‐associated autoantibodies during pregnancy and the transplacental transfer of these autoantibodies to the fetal…”
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Helicobacter pylori infection in Finnish children and adolescents. A serologic cross-sectional and follow-up study by Ashorn, M, Mäki, M, Hällström, M, Uhari, M, Akerblom, H K, Viikari, J, Miettinen, A

“…The purpose was to examine the epidemiology of Helicobacter pylori infection in Finnish children and adolescents. Blood samples taken from healthy subjects (n…”
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Increasing trend in Type 1 (insulin-dependent) diabetes mellitus in childhood in Finland : analysis of age, calendar time and birth cohort effects during 1965 to 1984 by TUOMILEHTO, J, REWERS, M, REUNANEN, A, LOUNAMAA, P, LOUNAMAA, R, TUOMILEHTO-WOLF, E, AKERBLOM, H. K

“…The Central Drug Registry in Finland ascertained 5,920 incident cases of Type 1 (insulin-dependent) diabetes mellitus diagnosed under the age of 15 years,…”
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to: Pani MA, Van Autreve J, Van Der Auwera BJ, Gorus FK, Badenhoop K (2002) Non-transmitted maternal HLA DQ2 or DQ8 alleles and risk of Type I diabetes in offspring: the importance of foetal or post partum exposure to diabetogenic molecules. Diabetologia 45:1340-1343 by Hermann, R, Veijola, R, Sipilä, I, Knip, M, Akerblom, H K, Simell, O, Ilonen, J

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Dietary manipulation of beta cell autoimmunity in infants at increased risk of type 1 diabetes: a pilot study by Åkerblom, H. K., Virtanen, S. M., Ilonen, J., Savilahti, E., Vaarala, O., Reunanen, A., Teramo, K., Hämäläinen, A.-M., Paronen, J., Riikjärv, M.-A., Ormisson, A., Ludvigsson, J., Dosch, H.-M., Hakulinen, T., Knip, M.

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Coeliac disease in children and adolescents with type 1 diabetes: a study of growth, glycaemic control, and experiences of families by Saukkonen, T, Väisänen, S, Åkerblom, HK

“…The aim of this study was to evaluate whether coeliac disease affects growth, glycaemic control, and general well‐being of children and adolescents with type 1…”
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Antibody cross‐reactivity induced by the homologous regions in glutamic acid decarboxylase (GAD65) and 2C protein of coxsackievirus B4 by LÖNNROT, M., HYÖTY, H., KNIP, M., ROIVAINEN, M., KULMALA, P., LEINIKKI, P., ÅKERBLOM, H. K.

“…GAD65 contains an amino acid sequence which is highly homologous with a sequence in the 2C protein of coxsackievirus B4 (CBV4‐2C). In the present study the…”
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Apolipoprotein E phenotypes and serum lipids in newborns and 3-year-old children : the cardiovascular risk in young finns study by LEHTIMÄKI, T, PORKKA, K, VIIKARI, J, EHNHOLM, C, ÅKERBLOM, H. K, NIKKARI, T

“…Apolipoprotein E (apoE) phenotype is a genetic determinant of plasma total cholesterol and low density lipoprotein (LDL) cholesterol concentrations, that are…”
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