Search Results - "Ángel Maestro, Miguel"

Hnf1α (MODY3) Controls Tissue-Specific Transcriptional Programs and Exerts Opposed Effects on Cell Growth in Pancreatic Islets and Liver by Servitja, Joan-Marc, Pignatelli, Miguel, Maestro, Miguel Ángel, Cardalda, Carina, Boj, Sylvia F., Lozano, Juanjo, Blanco, Enrique, Lafuente, Amàlia, McCarthy, Mark I., Sumoy, Lauro, Guigó, Roderic, Ferrer, Jorge

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Pancreas agenesis mutations disrupt a lead enhancer controlling a developmental enhancer cluster by Miguel-Escalada, Irene, Maestro, Miguel Ángel, Balboa, Diego, Elek, Anamaria, Bernal, Aina, Bernardo, Edgar, Grau, Vanessa, García-Hurtado, Javier, Sebé-Pedrós, Arnau, Ferrer, Jorge

“…Sequence variants in cis-acting enhancers are important for polygenic disease, but their role in Mendelian disease is poorly understood. Redundancy between…”
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Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants by Pasquali, Lorenzo, Gaulton, Kyle J, Rodríguez-Seguí, Santiago A, Mularoni, Loris, Miguel-Escalada, Irene, Akerman, İldem, Tena, Juan J, Morán, Ignasi, Gómez-Marín, Carlos, van de Bunt, Martijn, Ponsa-Cobas, Joan, Castro, Natalia, Nammo, Takao, Cebola, Inês, García-Hurtado, Javier, Maestro, Miguel Angel, Pattou, François, Piemonti, Lorenzo, Berney, Thierry, Gloyn, Anna L, Ravassard, Philippe, Skarmeta, José Luis Gómez, Müller, Ferenc, McCarthy, Mark I, Ferrer, Jorge

“…Jorge Ferrer and colleagues have mapped regulatory SNP variants associated in GWAS with type 2 diabetes risk and glycemic traits to large clusters of enhancer…”
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TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors by Cebola, Inês, Rodríguez-Seguí, Santiago A., Cho, Candy H-H., Bessa, José, Rovira, Meritxell, Luengo, Mario, Chhatriwala, Mariya, Berry, Andrew, Ponsa-Cobas, Joan, Maestro, Miguel Angel, Jennings, Rachel E., Pasquali, Lorenzo, Morán, Ignasi, Castro, Natalia, Hanley, Neil A., Gomez-Skarmeta, Jose Luis, Vallier, Ludovic, Ferrer, Jorge

“…The genomic regulatory programmes that underlie human organogenesis are poorly understood. Pancreas development, in particular, has pivotal implications for…”
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The biliary epithelium gives rise to liver progenitor cells by Rodrigo‐Torres, Daniel, Affò, Silvia, Coll, Mar, Morales‐Ibanez, Oriol, Millán, Cristina, Blaya, Delia, Alvarez‐Guaita, Anna, Rentero, Carles, Lozano, Juan José, Maestro, Miguel Angel, Solar, Myriam, Arroyo, Vicente, Caballería, Joan, van Grunsven, Leo A., Enrich, Carlos, Ginès, Pere, Bataller, Ramon, Sancho‐Bru, Pau

“…Severe liver diseases are characterized by expansion of liver progenitor cells (LPC), which correlates with disease severity. However, the origin and role of…”
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Derepression of Polycomb targets during pancreatic organogenesis allows insulin-producing beta-cells to adopt a neural gene activity program by van Arensbergen, Joris, García-Hurtado, Javier, Moran, Ignasi, Maestro, Miguel Angel, Xu, Xiaobo, Van de Casteele, Mark, Skoudy, Anouchka L, Palassini, Matteo, Heimberg, Harry, Ferrer, Jorge

“…The epigenome changes that underlie cellular differentiation in developing organisms are poorly understood. To gain insights into how pancreatic beta-cells are…”
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Pancreatic Exocrine Duct Cells Give Rise to Insulin-Producing β Cells during Embryogenesis but Not after Birth by Solar, Myriam, Cardalda, Carina, Houbracken, Isabelle, Martín, Mercè, Maestro, Miguel Angel, De Medts, Nele, Xu, Xiaobo, Grau, Vanessa, Heimberg, Harry, Bouwens, Luc, Ferrer, Jorge

“…A longstanding unsettled question is whether pancreatic β cells originate from exocrine duct cells. We have now used genetic labeling to fate map embryonic and…”
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The HASTER lncRNA promoter is a cis-acting transcriptional stabilizer of HNF1A by Beucher, Anthony, Miguel-Escalada, Irene, Balboa, Diego, De Vas, Matías G., Maestro, Miguel Angel, Garcia-Hurtado, Javier, Bernal, Aina, Gonzalez-Franco, Roser, Vargiu, Pierfrancesco, Heyn, Holger, Ravassard, Philippe, Ortega, Sagrario, Ferrer, Jorge

“…The biological purpose of long non-coding RNAs (lncRNAs) is poorly understood. Haploinsufficient mutations in HNF1A homeobox A ( HNF1A ), encoding a…”
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REST is a major negative regulator of endocrine differentiation during pancreas organogenesis by Rovira, Meritxell, Atla, Goutham, Maestro, Miguel Angel, Grau, Vane, García-Hurtado, Javier, Maqueda, Maria, Mosquera, Jose Luis, Yamada, Yasuhiro, Kerr-Conte, Julie, Pattou, Francois, Ferrer, Jorge

“…Multiple transcription factors have been shown to promote pancreatic β-cell differentiation, yet much less is known about negative regulators. Earlier…”
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Diastereo- and Enantioselective Synthesis of Novel β-Lactam-Containing 1,4-Benzodiazepines through a Ketene−Imine Cycloaddition Reaction by del Pozo, Carlos, Macías, Alberto, López-Ortiz, Fernando, Ángel Maestro, Miguel, Alonso, Eduardo, González, Javier

“…Novel tricyclic scaffolds that incorporate a β‐lactam ring fused to the d bond of a 1,4‐benzodiazepine seven‐membered ring have been synthesized in a process…”
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Neonatal diabetes mutations disrupt a chromatin pioneering function that activates the human insulin gene by Akerman, Ildem, Maestro, Miguel Angel, De Franco, Elisa, Grau, Vanessa, Flanagan, Sarah, García-Hurtado, Javier, Mittler, Gerhard, Ravassard, Philippe, Piemonti, Lorenzo, Ellard, Sian, Hattersley, Andrew T., Ferrer, Jorge

“…Despite the central role of chromosomal context in gene transcription, human noncoding DNA variants are generally studied outside of their genomic location…”
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Recessive mutations in the INS gene result in neonatal diabetes through reduced insulin biosynthesis by Garin, Intza, Edghill, Emma L, Akerman, Ildem, Rubio-Cabezas, Oscar, Rica, Itxaso, Locke, Jonathan M, Maestro, Miguel Angel, Alshaikh, Adnan, Bundak, Ruveyde, del Castillo, Gabriel, Deeb, Asma, Deiss, Dorothee, Fernandez, Juan M, Godbole, Koumudi, Hussain, Khalid, O'Connell, Michele, Klupa, Thomasz, Kolouskova, Stanislava, Mohsin, Fauzia, Perlman, Kusiel, Sumnik, Zdenek, Rial, Jose M, Ugarte, Estibaliz, Vasanthi, Thiruvengadam, Johnstone, Karen, Flanagan, Sarah E, Martínez, Rosa, Castaño, Carlos, Patch, Ann-Marie, Fernández-Rebollo, Eduardo, Raile, Klemens, Morgan, Noel, Harries, Lorna W, Castaño, Luis, Ellard, Sian, Ferrer, Jorge, de Nanclares, Guiomar Perez, Hattersley, Andrew T

“…Heterozygous coding mutations in the INS gene that encodes preproinsulin were recently shown to be an important cause of permanent neonatal diabetes. These…”
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Ring1b bookmarks genes in pancreatic embryonic progenitors for repression in adult β cells by van Arensbergen, Joris, García-Hurtado, Javier, Maestro, Miguel Angel, Correa-Tapia, Miguel, Rutter, Guy A, Vidal, Miguel, Ferrer, Jorge

“…Polycomb-mediated gene repression is essential for embryonic development, yet its precise role in lineage-specific programming is poorly understood. Here we…”
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Ins1 Cre knock-in mice for beta cell-specific gene recombination by Thorens, Bernard, Tarussio, David, Maestro, Miguel Angel, Rovira, Meritxell, Heikkilä, Eija, Ferrer, Jorge

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Better Performance of Monodentate P-Stereogenic Phosphanes Compared to Bidentate Analogues in Pd-Catalyzed Asymmetric Allylic Alkylations by Grabulosa, Arnald, Muller, Guillermo, Ceder, Rosa, Maestro, Miguel Ángel

“…The cationic allylpalladium complexes 3a–3f, 4a, 4e, 5e of type [Pd(η3‐2‐Me‐C3H4)P2]PF6 were synthesized using a group of monodentate P‐stereogenic phosphanes,…”
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Hnf1α (MODY3) Regulates β-Cell-Enriched MafA Transcription Factor Expression by Hunter, Chad S, Maestro, Miguel Angel, Raum, Jeffrey C, Guo, Min, Thompson, Frederick H, Ferrer, Jorge, Stein, Roland

“…The MODY Hnf1α transcription factor activates endogenous MafA expression in pancreatic β-cells by binding within the Region 3 control domain. The expression…”
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Bis(oxazoline) Ligands Containing Four and Five Spacer Atoms:  Palladium Complexes and Catalytic Behavior by Gómez, Montserrat, Jansat, Susanna, Muller, Guillermo, Maestro, Miguel Angel, Mahía, José

“…Chiral bis(oxazoline) ligands with biphenyl (A−E) and diphenyl ether and dibenzofuran (F and G, respectively) backbones were prepared, and their coordination…”
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Ins1(Cre) knock-in mice for beta cell-specific gene recombination by Thorens, Bernard, Tarussio, David, Maestro, Miguel Angel, Rovira, Meritxell, Heikkilä, Eija, Ferrer, Jorge

“…Pancreatic beta cells play a central role in the control of glucose homeostasis by secreting insulin to stimulate glucose uptake by peripheral tissues…”
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Allylpalladium Complexes with P-Stereogenic Monodentate Phosphines. Application in the Asymmetric Hydrovinylation of Styrene by Grabulosa, Arnald, Muller, Guillermo, Ordinas, Juan I, Mezzetti, Antonio, Maestro, Miguel Ángel, Font-Bardia, Mercè, Solans, Xavier

“…A group of P-stereogenic monodentate phosphines S-PPhRR‘ (R = 1-naphthyl, 9-phenanthryl, or o-biphenylyl and R‘ = CH3−, i-C3H8−, and Ph3SiCH2−) have been…”
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Synthesis, Characterization, and Magnetic Properties of Self-assembled Compounds Based on Discrete Homotrinuclear Complexes of Cu(II) by Tercero, Javier, Diaz, Carmen, El Fallah, Mohamed Salah, Ribas, Joan, Solans, Xavier, Maestro, Miguel Angel, Mahía, José

“…Three new supramolecular entities of Cu(II) were synthesized and characterized:  [{Cu(H2O)(tmen)}2{μ-Cu(H2O)(opba)}]2{(ClO4)2}2·2H2O (1),…”
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