Search Results - "Álamo, C"

Intraventricular flow patterns and stasis in the LVAD-assisted heart by Wong, K, Samaroo, G, Ling, I, Dembitsky, W, Adamson, R, del Álamo, J.C, May-Newman, K

“…Abstract Left ventricular assist device (LVAD) support disrupts the natural blood flow path through the heart, introducing flow patterns associated with…”
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Cyclic Mechanical Stresses Alter Erythrocyte Membrane Composition and Microstructure and Trigger Macrophage Phagocytosis by Garcia‐Herreros, Antoni, Yeh, Yi‐Ting, Peng, Zhangli, del Álamo, Juan C.

“…Red blood cells (RBCs) are cleared from the circulation when they become damaged or display aging signals targeted by macrophages. This process occurs mainly…”
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Peripheral Th17 cells expressing β7 intestinal homing receptor in recent and chronic HIV infections by Márquez‐Coello, M., Montes‐de‐Oca Arjona, M., Fernández‐Gutiérrez del Álamo, C., Ruiz‐Sánchez, C., Girón‐González, J. A.

“…Summary The objective of this study was to conduct an analysis of peripheral blood Th17 cells with the ability to home to gut mucosa (CD4+Th17+β7+) during…”
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Correction to ‘Coordination of contractility, adhesion and flow in migrating Physarum amoebae’ by Lewis, Owen L., Zhang, Shun, Guy, Robert D., del Álamo, Juan C.

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Use of human induced pluripotent stem cell–derived cardiomyocytes to assess drug cardiotoxicity by Sharma, Arun, McKeithan, Wesley L., Serrano, Ricardo, Kitani, Tomoya, Burridge, Paul W., del Álamo, Juan C., Mercola, Mark, Wu, Joseph C.

“…Cardiotoxicity has historically been a major cause of drug removal from the pharmaceutical market. Several chemotherapeutic compounds have been noted for their…”
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In situ mechanotransduction via vinculin regulates stem cell differentiation by Holle, Andrew W., Tang, Xinyi, Vijayraghavan, Deepthi, Vincent, Ludovic G., Fuhrmann, Alexander, Choi, Yu Suk, Álamo, Juan C., Engler, Adam J.

“…Human mesenchymal stem cell (hMSC) proliferation, migration, and differentiation have all been linked to extracellular matrix stiffness, yet the signaling…”
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Contribution of the Diastolic Vortex Ring to Left Ventricular Filling by Martínez-Legazpi, Pablo, MEng, PhD, Bermejo, Javier, MD, PhD, Benito, Yolanda, DCS, DVM, Yotti, Raquel, MD, PhD, Pérez del Villar, Candelas, MD, González-Mansilla, Ana, MD, PhD, Barrio, Alicia, DCS, MBiol, Villacorta, Eduardo, MD, Sánchez, Pedro L., MD, PhD, Fernández-Avilés, Francisco, MD, PhD, del Álamo, Juan C., AeEng, PhD

“…Abstract Background Intraventricular fluid dynamics can be assessed clinically using imaging. The contribution of vortex structures to left ventricular (LV)…”
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Mesenchymal stem cell durotaxis depends on substrate stiffness gradient strength by Vincent, Ludovic G., Choi, Yu Suk, Alonso-Latorre, Baldomero, del Álamo, Juan C., Engler, Adam J.

“…Mesenchymal stem cells (MSCs) respond to the elasticity of their environment, which varies between and within tissues. Stiffness gradients within tissues can…”
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High-throughput screening of tyrosine kinase inhibitor cardiotoxicity with human induced pluripotent stem cells by Sharma, Arun, Burridge, Paul W, McKeithan, Wesley L, Serrano, Ricardo, Shukla, Praveen, Sayed, Nazish, Churko, Jared M, Kitani, Tomoya, Wu, Haodi, Holmström, Alexandra, Matsa, Elena, Zhang, Yuan, Kumar, Anusha, Fan, Alice C, Del Álamo, Juan C, Wu, Sean M, Moslehi, Javid J, Mercola, Mark, Wu, Joseph C

“…Tyrosine kinase inhibitors (TKIs), despite their efficacy as anticancer therapeutics, are associated with cardiovascular side effects ranging from induced…”
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High throughput physiological screening of iPSC-derived cardiomyocytes for drug development by del Álamo, Juan C., Lemons, Derek, Serrano, Ricardo, Savchenko, Alex, Cerignoli, Fabio, Bodmer, Rolf, Mercola, Mark

“…Cardiac drug discovery is hampered by the reliance on non-human animal and cellular models with inadequate throughput and physiological fidelity to accurately…”
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Three-dimensional quantification of cellular traction forces and mechanosensing of thin substrata by fourier traction force microscopy by del Álamo, Juan C, Meili, Ruedi, Álvarez-González, Begoña, Alonso-Latorre, Baldomero, Bastounis, Effie, Firtel, Richard, Lasheras, Juan C

“…We introduce a novel three-dimensional (3D) traction force microscopy (TFM) method motivated by the recent discovery that cells adhering on plane surfaces…”
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Demonstration of Patient-Specific Simulations to Assess Left Atrial Appendage Thrombogenesis Risk by García-Villalba, Manuel, Rossini, Lorenzo, Gonzalo, Alejandro, Vigneault, Davis, Martinez-Legazpi, Pablo, Durán, Eduardo, Flores, Oscar, Bermejo, Javier, McVeigh, Elliot, Kahn, Andrew M, Del Álamo, Juan C

“…Atrial fibrillation (AF) alters left atrial (LA) hemodynamics, which can lead to thrombosis in the left atrial appendage (LAA), systemic embolism and stroke. A…”
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Hepatocyte growth factor and chronic hepatitis C by Marín-Serrano, E, Rodríguez-Ramos, C, Díaz-García, F, Martín-Herrera, L, Fernández-Gutiérrez-Del-Alamo, C, Girón-González, J A

“…The hepatocyte growth factor (HGF) is a pleiotropic cytokine produced by hepatic stellate cells and implicated in liver regeneration and fibrosis. Serum levels…”
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Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread by Lamason, Rebecca L., Bastounis, Effie, Kafai, Natasha M., Serrano, Ricardo, del Álamo, Juan C., Theriot, Julie A., Welch, Matthew D.

“…Spotted fever group (SFG) rickettsiae are human pathogens that infect cells in the vasculature. They disseminate through host tissues by a process of…”
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3D Traction Stresses Activate Protease-Dependent Invasion of Cancer Cells by Aung, Aereas, Seo, Young N., Lu, Shaoying, Wang, Yingxiao, Jamora, Colin, del Álamo, Juan C., Varghese, Shyni

“…Cell invasion and migration that occurs, for example, in cancer metastasis is rooted in the ability of cells to navigate through varying levels of physical…”
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Deriving phenotype-representative left ventricular flow patterns by reduced-order modeling and classification by Borja, María Guadalupe, Martinez-Legazpi, Pablo, Nguyen, Cathleen, Flores, Oscar, Kahn, Andrew M., Bermejo, Javier, del Álamo, Juan C.

“…Extracting phenotype-representative flow patterns and their associated numerical metrics is a bottleneck in the clinical translation of advanced cardiac flow…”
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Spatio-Temporal Analysis of Eukaryotic Cell Motility by Improved Force Cytometry by Álamo, Juan C. del, Meili, Ruedi, Alonso-Latorre, Baldomero, Rodríguez-Rodríguez, Javier, Aliseda, Alberto, Firtel, Richard A., Lasheras, Juan C.

“…Cell motility plays an essential role in many biological systems, but precise quantitative knowledge of the biophysical processes involved in cell migration is…”
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Biomechanics of parasite migration within hosts by Yeh, Yi-Ting, del Álamo, Juan C., Caffrey, Conor R.

“…The quantification of parasite forces during migration in host environments elucidates critical biophysical mechanisms that support parasite survival and…”
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Coordination of contractility, adhesion and flow in migrating Physarum amoebae by Lewis, Owen L., Zhang, Shun, Guy, Robert D., del Álamo, Juan C.

“…This work examines the relationship between spatio-temporal coordination of intracellular flow and traction stress and the speed of amoeboid locomotion of…”
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Three-dimensional forces exerted by leukocytes and vascular endothelial cells dynamically facilitate diapedesis by Yeh, Yi-Ting, Serrano, Ricardo, François, Joshua, Chiu, Jeng-Jiann, Li, Yi-Shuan Julie, del Álamo, Juan C., Chien, Shu, Lasheras, Juan C.

“…Leukocyte transmigration across vessel walls is a critical step in the innate immune response. Upon their activation and firm adhesion to vascular endothelial…”
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