Search Results - "Ábrigo, Johanna"

Role of Oxidative Stress as Key Regulator of Muscle Wasting during Cachexia by Cabello-Verrugio, Claudio, Cabrera, Daniel, Simon, F., Vilos, Cristian, Riedel, C. A., Elorza, Alvaro A., Abrigo, Johanna, Estrada, Lisbell

“…Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of muscular mass and the contractile capacity of the skeletal muscle as a…”
Get full text

TGF-β requires the activation of canonical and non-canonical signalling pathways to induce skeletal muscle atrophy by Ábrigo, Johanna, Campos, Fabian, Simon, Felipe, Riedel, Claudia, Cabrera, Daniel, Vilos, Cristian, Cabello-Verrugio, Claudio

“…The transforming growth factor type-beta (TGF-β) induces skeletal muscle atrophy characterised by a decrease in the fibre's diameter and levels of myosin heavy…”
Get more information

Angiotensin-(1-7) Prevents Skeletal Muscle Atrophy Induced by Transforming Growth Factor Type Beta (TGF-β) via Mas Receptor Activation by Ábrigo, Johanna, Simon, Felipe, Cabrera, Daniel, Cabello-Verrugio, Claudio

“…Background: Transforming growth factor type beta 1 (TGF-β1) produces skeletal muscle atrophy. Angiotensin-(1-7) (Ang-(1-7)), through the Mas receptor, prevents…”
Get full text

The Ang-(1-7)/Mas-1 axis attenuates the expression and signalling of TGF-β1 induced by AngII in mouse skeletal muscle by Morales, María Gabriela, Abrigo, Johanna, Meneses, Carla, Simon, Felipe, Cisternas, Franco, Rivera, Juan Carlos, Vazquez, Yaneisi, Cabello-Verrugio, Claudio

“…AngII (angiotensin II) induces pathological conditions such as fibrosis in skeletal muscle. In this process, AngII increases ROS (reactive oxygen species) and…”
Get more information

The p75NTR neurotrophin receptor is required to organize the mature neuromuscular synapse by regulating synaptic vesicle availability by Pérez, Viviana, Bermedo-Garcia, Francisca, Zelada, Diego, Court, Felipe A, Pérez, Miguel Ãngel, Fuenzalida, Marco, Ãbrigo, Johanna, Cabello-Verrugio, Claudio, Moya-Alvarado, Guillermo, Tapia, Juan Carlos, Valenzuela, Vicente, Hetz, Claudio, Bronfman, Francisca C, Henríquez, Juan Pablo

“…The coordinated movement of organisms relies on efficient nerve-muscle communication at the neuromuscular junction. After peripheral nerve injury or…”
Get full text

Mitochondrial Dysfunction in Skeletal Muscle Pathologies by Abrigo, Johanna, Simon, Felipe, Cabrera, Daniel, Vilos, Cristian, Cabello-Verrugio, Claudio

“…Several molecular mechanisms are involved in the regulation of skeletal muscle function. Among them, mitochondrial activity can be identified. The mitochondria…”
Get more information

Protective Effect of Angiotensin 1-7 on Sarcopenia Induced by Chronic Liver Disease in Mice by Aguirre, Francisco, Abrigo, Johanna, Gonzalez, Francisco, Gonzalez, Andrea, Simon, Felipe, Cabello-Verrugio, Claudio

“…Sarcopenia associated with chronic liver disease (CLD) is one of the more common extrahepatic features in patients with these pathologies. Among the cellular…”
Get full text

Angiotensin (1-7) Decreases Myostatin-Induced NF-κB Signaling and Skeletal Muscle Atrophy by Aravena, Javier, Abrigo, Johanna, Gonzalez, Francisco, Aguirre, Francisco, Gonzalez, Andrea, Simon, Felipe, Cabello-Verrugio, Claudio

“…Myostatin is a myokine that regulates muscle function and mass, producing muscle atrophy. Myostatin induces the degradation of myofibrillar proteins, such as…”
Get full text

The angiotensin-(1–7)/Mas axis reduces myonuclear apoptosis during recovery from angiotensin II-induced skeletal muscle atrophy in mice by Meneses, Carla, Morales, María Gabriela, Abrigo, Johanna, Simon, Felipe, Brandan, Enrique, Cabello-Verrugio, Claudio

“…Angiotensin-(1–7) [Ang (1–7)] is a peptide belonging to the non-classical renin-angiotensin system (RAS). Ang (1–7), through its receptor Mas, has an opposite…”
Get full text

Angiotensin-(1-7) decreases skeletal muscle atrophy induced by angiotensin II through a Mas receptor-dependent mechanism by Cisternas, Franco, Morales, María Gabriela, Meneses, Carla, Simon, Felipe, Brandan, Enrique, Abrigo, Johanna, Vazquez, Yaneisi, Cabello-Verrugio, Claudio

“…Skeletal muscle atrophy is a pathological condition characterized by the loss of strength and muscle mass, an increase in myosin heavy chain (MHC) degradation…”
Get more information

Cholic and deoxycholic acids induce mitochondrial dysfunction, impaired biogenesis and autophagic flux in skeletal muscle cells by Abrigo, Johanna, Olguín, Hugo, Tacchi, Franco, Orozco-Aguilar, Josué, Valero-Breton, Mayalen, Soto, Jorge, Castro-Sepúlveda, Mauricio, Elorza, Alvaro A, Simon, Felipe, Cabello-Verrugio, Claudio

“…Skeletal muscle is sensitive to bile acids (BA) because it expresses the TGR5 receptor for BA. Cholic (CA) and deoxycholic (DCA) acids induce a sarcopenia-like…”
Get full text

High Fat Diet-Induced Skeletal Muscle Wasting Is Decreased by Mesenchymal Stem Cells Administration: Implications on Oxidative Stress, Ubiquitin Proteasome Pathway Activation, and Myonuclear Apoptosis by Cabello-Verrugio, Claudio, Ezquer, Fernando, Simon, F., Cabrera, Daniel, Aravena, Javier, Rivera, Juan Carlos, Abrigo, Johanna, Ezquer, Marcelo E.

“…Obesity can lead to skeletal muscle atrophy, a pathological condition characterized by the loss of strength and muscle mass. A feature of muscle atrophy is a…”
Get full text

Sarcopenia Induced by Chronic Liver Disease in Mice Requires the Expression of the Bile Acids Membrane Receptor TGR5 by Abrigo, Johanna, Campos, Fabián, Gonzalez, Francisco, Aguirre, Francisco, Gonzalez, Andrea, Huerta-Salgado, Camila, Conejeros, Sabrina, Simon, Felipe, Arrese, Marco, Cabrera, Daniel, Elorza, Alvaro A, Cabello-Verrugio, Claudio

“…Sarcopenia is a condition of muscle dysfunction, commonly associated with chronic liver disease (CLD), characterized by a decline in muscle strength, the…”
Get full text

Angiotensin-(1-7) attenuates disuse skeletal muscle atrophy in mice via its receptor, Mas by Morales, María Gabriela, Abrigo, Johanna, Acuña, María José, Santos, Robson A, Bader, Michael, Brandan, Enrique, Simon, Felipe, Olguin, Hugo, Cabrera, Daniel, Cabello-Verrugio, Claudio

“…Immobilization is a form of disuse characterized by a loss of strength and muscle mass. Among the main features are decreased IGF-1/Akt signalling and…”
Get full text

Central Role of Transforming Growth Factor Type Beta 1 in Skeletal Muscle Dysfunctions: An Update on Therapeutic Strategies by Abrigo, Johanna, Simon, Felipe, Cabrera, Daniel, Cordova, Gonzalo, Trollet, Capucine, Cabello-Verrugio, Claudio

“…Among the soluble factors that regulate skeletal muscle function, Transforming Growth Factor type Beta 1 (TGF-β1) is one of the most studied. This factor…”
Get more information

Angiotensin-(1-7) Prevents Lipopolysaccharide-Induced Autophagy via the Mas Receptor in Skeletal Muscle by Rivera, Juan Carlos, Abrigo, Johanna, Tacchi, Franco, Simon, Felipe, Brandan, Enrique, Santos, Robson A, Bader, Michael, Chiong, Mario, Cabello-Verrugio, Claudio

“…Skeletal muscle atrophy, which occurs in lipopolysaccharide (LPS)-induced sepsis, causes a severe muscle function reduction. The increased autophagy…”
Get full text

Angiotensin-(1-7) improves skeletal muscle regeneration by Valero-Breton, Mayalen, Tacchi, Franco, Abrigo, Johanna, Simon, Felipe, Cabrera, Daniel, Cabello-Verrugio, Claudio

“…Skeletal muscle possesses regenerative potential via satellite cells, compromised in muscular dystrophies leading to fibrosis and fat infiltration. Angiotensin…”
Get full text

Expression of the Mas receptor is upregulated in skeletal muscle wasting by Morales, María Gabriela, Abrigo, Johanna, Meneses, Carla, Cisternas, Franco, Simon, Felipe, Cabello-Verrugio, Claudio

“…Skeletal muscle atrophy during sepsis, immobilization, and chronic diseases is characterized by an increase in expression and activity of the muscle-specific…”
Get full text

Bile Acids Induce Alterations in Mitochondrial Function in Skeletal Muscle Fibers by Abrigo, Johanna, Olguín, Hugo, Gutierrez, Danae, Tacchi, Franco, Arrese, Marco, Cabrera, Daniel, Valero-Breton, Mayalen, Elorza, Alvaro A, Simon, Felipe, Cabello-Verrugio, Claudio

“…Cholestatic chronic liver disease is characterized by developing sarcopenia and elevated serum levels of bile acids. Sarcopenia is a skeletal muscle disorder…”
Get full text

Somatotropic Axis Dysfunction in Non-Alcoholic Fatty Liver Disease: Beneficial Hepatic and Systemic Effects of Hormone Supplementation by Cabrera, Daniel, Cabello-Verrugio, Claudio, Solís, Nancy, San Martín, Diego, Cofré, Catalina, Pizarro, Margarita, Arab, Juan Pablo, Abrigo, Johanna, Campos, Fabián, Irigoyen, Betzabé, Carrasco-Avino, Gonzalo, Bezares, Katiuska, Riquelme, Valentina, Riquelme, Arnoldo, Arrese, Marco, Barrera, Francisco

“…Somatotropic axis dysfunction associated with non-alcoholic fatty liver disease (NAFLD) has potential multisystemic detrimental effects. Here, we analysed the…”
Get full text