Search Results - "'T Hart, Leen M"

Apolipoprotein-CIII O-Glycosylation, a Link between GALNT2 and Plasma Lipids by Naber, Annemieke, Demus, Daniel, Slieker, Roderick, Nicolardi, Simone, Beulens, Joline W. J., Elders, Petra J. M., Lieverse, Aloysius G., Sijbrands, Eric J. G., ’t Hart, Leen M., Wuhrer, Manfred, van Hoek, Mandy

“…Apolipoprotein-CIII (apo-CIII) is involved in triglyceride-rich lipoprotein metabolism and linked to beta-cell damage, insulin resistance, and cardiovascular…”
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Apolipoprotein-CIII O-Glycosylation Is Associated with Micro- and Macrovascular Complications of Type 2 Diabetes by Naber, Annemieke, Demus, Daniel, Slieker, Roderick C, Nicolardi, Simone, Beulens, Joline W J, Elders, Petra J M, Lieverse, Aloysius G, Sijbrands, Eric J G, 't Hart, Leen M, Wuhrer, Manfred, van Hoek, Mandy

“…Apolipoprotein-CIII (apo-CIII) inhibits the clearance of triglycerides from circulation and is associated with an increased risk of diabetes complications. It…”
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Visit-to-visit variability of glycemia and vascular complications: the Hoorn Diabetes Care System cohort by Slieker, Roderick C, van der Heijden, Amber A W H, Nijpels, Giel, Elders, Petra J M, 't Hart, Leen M, Beulens, Joline W J

“…Glycemic variation has been suggested to be a risk factor for diabetes-related complications. Previous studies did not address confounding of diabetes…”
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Genomics Research of Lifetime Depression in the Netherlands: The BIObanks Netherlands Internet Collaboration (BIONIC) Project by Huider, Floris, Milaneschi, Yuri, Hottenga, Jouke-Jan, Bot, Mariska, Rietman, M Liset, Kok, Almar A L, Galesloot, Tessel E, 't Hart, Leen M, Rutters, Femke, Blom, Marieke T, Rhebergen, Didi, Visser, Marjolein, Brouwer, Ingeborg, Feskens, Edith, Hartman, Catharina A, Oldehinkel, Albertine J, de Geus, Eco J C, Kiemeney, Lambertus A, Huisman, Martijn, Picavet, H Susan J, Verschuren, W M Monique, van Loo, Hanna M, Penninx, Brenda W J H, Boomsma, Dorret I

“…In this cohort profile article we describe the lifetime major depressive disorder (MDD) database that has been established as part of the BIObanks Netherlands…”
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Multi-omics subgroups associated with glycaemic deterioration in type 2 diabetes: an IMI-RHAPSODY Study by Li, Shiying, Dragan, Iulian, Tran, Van Du T, Fung, Chun Ho, Kuznetsov, Dmitry, Hansen, Michael K, Beulens, Joline W J, Hart, Leen M 't, Slieker, Roderick C, Donnelly, Louise A, Gerl, Mathias J, Klose, Christian, Mehl, Florence, Simons, Kai, Elders, Petra J M, Pearson, Ewan R, Rutter, Guy A, Ibberson, Mark

“…Type 2 diabetes (T2D) onset, progression and outcomes differ substantially between individuals. Multi-omics analyses may allow a deeper understanding of these…”
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Plasma protein N-glycosylation is associated with cardiovascular disease, nephropathy, and retinopathy in type 2 diabetes by Memarian, Elham, 't Hart, Leen M, Slieker, Roderick C, Lemmers, Roosmarijn F L, van der Heijden, Amber A, Rutters, Femke, Nijpels, Giel, Schoep, Emma, Lieverse, Aloysius G, Sijbrands, Eric J G, Wuhrer, Manfred, van Hoek, Mandy, Dotz, Viktoria

“…IntroductionAlthough associations of total plasma N-glycome (TPNG) with type 2 diabetes have been reported, little is known on the role of TPNG in type 2…”
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Sex steroids affect triglyceride handling, glucose-dependent insulinotropic polypeptide, and insulin sensitivity: a 1-week randomized clinical trial in healthy young men by Lapauw, Bruno, Ouwens, Margriet, 't Hart, Leen M, Wuyts, Birgitte, Holst, Jens J, T'Sjoen, Guy, Kaufman, Jean-Marc, Ruige, Johannes B

“…To evaluate metabolic effects of sex steroids in nonfasting and fasting conditions, independent from changes in body composition. A randomized clinical trial…”
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Replication and cross-validation of type 2 diabetes subtypes based on clinical variables: an IMI-RHAPSODY study by Slieker, Roderick C., Donnelly, Louise A., Fitipaldi, Hugo, Bouland, Gerard A., Giordano, Giuseppe N., Åkerlund, Mikael, Gerl, Mathias J., Ahlqvist, Emma, Ali, Ashfaq, Dragan, Iulian, Festa, Andreas, Hansen, Michael K., Mansour Aly, Dina, Kim, Min, Kuznetsov, Dmitry, Mehl, Florence, Klose, Christian, Simons, Kai, Pavo, Imre, Pullen, Timothy J., Suvitaival, Tommi, Wretlind, Asger, Rossing, Peter, Lyssenko, Valeriya, Legido-Quigley, Cristina, Groop, Leif, Thorens, Bernard, Franks, Paul W., Ibberson, Mark, Rutter, Guy A., Beulens, Joline W. J., ‘t Hart, Leen M., Pearson, Ewan R.

“…Aims/hypothesis Five clusters based on clinical characteristics have been suggested as diabetes subtypes: one autoimmune and four subtypes of type 2 diabetes…”
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Discovery of predictors of sudden cardiac arrest in diabetes: rationale and outline of the RESCUED (REcognition of Sudden Cardiac arrest vUlnErability in Diabetes) project by van Dongen, Laura H, Harms, Peter P, Hoogendoorn, Mark, Zimmerman, Dominic S, Lodder, Elisabeth M, 't Hart, Leen M, Herings, Ron, van Weert, Henk C P M, Nijpels, Giel, Swart, Karin M A, van der Heijden, Amber A, Blom, Marieke T, Elders, Petra J, Tan, Hanno L

“…IntroductionEarly recognition of individuals with increased risk of sudden cardiac arrest (SCA) remains challenging. SCA research so far has used data from…”
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Circulating small non‐coding RNAs are associated with the insulin‐resistant and obesity‐related type 2 diabetes clusters by Klerk, Juliette A., Beulens, Joline W. J., Bijkerk, Roel, Zonneveld, Anton Jan, Elders, Petra J. M., ’t Hart, Leen M., Slieker, Roderick

“…Aim To uncover differences in small non‐coding RNAs (sncRNAs) in individuals with type 2 diabetes (T2D) categorized into five clusters based on individual…”
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IgG N-glycans are associated with prevalent and incident complications of type 2 diabetes by Memarian, Elham, Heijmans, Ralph, Slieker, Roderick C, Sierra, Adriana, Gornik, Olga, Beulens, Joline W J, Hanic, Maja, Elders, Petra, Pascual, Julio, Sijbrands, Eric, Lauc, Gordan, Dotz, Viktoria, Barrios, Clara, 't Hart, Leen M, Wuhrer, Manfred, van Hoek, Mandy

“…Inflammation is important in the development of type 2 diabetes complications. The N-glycosylation of IgG influences its role in inflammation. To date, the…”
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An omics-based machine learning approach to predict diabetes progression: a RHAPSODY study by Slieker, Roderick C., Münch, Magnus, Donnelly, Louise A., Bouland, Gerard A., Dragan, Iulian, Kuznetsov, Dmitry, Elders, Petra J. M., Rutter, Guy A., Ibberson, Mark, Pearson, Ewan R., ’t Hart, Leen M., van de Wiel, Mark A., Beulens, Joline W. J.

“…Aims/hypothesis People with type 2 diabetes are heterogeneous in their disease trajectory, with some progressing more quickly to insulin initiation than…”
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Plasma Metabolomics Identifies Markers of Impaired Renal Function: A Meta-analysis of 3089 Persons with Type 2 Diabetes by Tofte, Nete, Vogelzangs, Nicole, Mook-Kanamori, Dennis, Brahimaj, Adela, Nano, Jana, Ahmadizar, Fariba, van Dijk, Ko Willems, Frimodt-Møller, Marie, Arts, Ilja, Beulens, Joline W J, Rutters, Femke, van der Heijden, Amber A, Kavousi, Maryam, Stehouwer, Coen D A, Nijpels, Giel, van Greevenbroek, Marleen M J, van der Kallen, Carla J H, Rossing, Peter, Ahluwalia, Tarunveer S, 't Hart, Leen M

“…There is a need for novel biomarkers and better understanding of the pathophysiology of diabetic kidney disease. To investigate associations between plasma…”
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Diabetes risk loci-associated pathways are shared across metabolic tissues by Bouland, Gerard A, Beulens, Joline W J, Nap, Joey, van der Slik, Arno R, Zaldumbide, Arnaud, 't Hart, Leen M, Slieker, Roderick C

“…Numerous genome-wide association studies have been performed to understand the influence of genetic variation on type 2 diabetes etiology. Many identified…”
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The endothelial function biomarker soluble E‐selectin is associated with nonalcoholic fatty liver disease by Simons, Nynke, Bijnen, Mitchell, Wouters, Kristiaan A. M., Rensen, Sander S., Beulens, Joline W. J., Greevenbroek, Marleen M. J., ’t Hart, Leen M., Greve, Jan Willem M., Kallen, Carla J. H., Schaper, Nicolaas C., Schalkwijk, Casper G., Stehouwer, Coen D. A., Brouwers, Martijn C. G. J.

“…Background & Aims Plasma soluble E‐selectin (sE‐selectin) is a frequently used biomarker of systemic endothelial dysfunction. The present study explored the…”
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HbA1c is associated with altered expression in blood of cell cycle- and immune response-related genes by Slieker, Roderick C., van der Heijden, Amber A. W. A., van Leeuwen, Nienke, Mei, Hailiang, Nijpels, Giel, Beulens, Joline W. J., ’t Hart, Leen M.

“…Aims/hypothesis Individuals with type 2 diabetes are heterogeneous in their glycaemic control as tracked by blood HbA 1c levels. Here, we investigated the…”
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Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study by Obura, Morgan, Beulens, Joline W J, Slieker, Roderick, Koopman, Anitra D M, Hoekstra, Trynke, Nijpels, Giel, Elders, Petra, Koivula, Robert W, Kurbasic, Azra, Laakso, Markku, Hansen, Tue H, Ridderstråle, Martin, Hansen, Torben, Pavo, Imre, Forgie, Ian, Jablonka, Bernd, Ruetten, Hartmut, Mari, Andrea, McCarthy, Mark I, Walker, Mark, Heggie, Alison, McDonald, Timothy J, Perry, Mandy H, De Masi, Federico, Brunak, Søren, Mahajan, Anubha, Giordano, Giuseppe N, Kokkola, Tarja, Dermitzakis, Emmanouil, Viñuela, Ana, Pedersen, Oluf, Schwenk, Jochen M, Adamski, Jurek, Teare, Harriet J A, Pearson, Ewan R, Franks, Paul W, 't Hart, Leen M, Rutters, Femke

“…Subclasses of different glycaemic disturbances could explain the variation in characteristics of individuals with type 2 diabetes (T2D). We aimed to examine…”
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Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D, THADA, ADAMTS9, BCL11A, and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function by Simonis-Bik, Annemarie M, Nijpels, Giel, van Haeften, Timon W, Houwing-Duistermaat, Jeanine J, Boomsma, Dorret I, Reiling, Erwin, van Hove, Els C, Diamant, Michaela, Kramer, Mark H H, Heine, Robert J, Maassen, J Antonie, Slagboom, P Eline, Willemsen, Gonneke, Dekker, Jacqueline M, Eekhoff, Elisabeth M, de Geus, Eco J, 't Hart, Leen M

“…Gene Variants in the Novel Type 2 Diabetes Loci CDC123/CAMK1D , THADA , ADAMTS9 , BCL11A , and MTNR1B Affect Different Aspects of Pancreatic β-Cell Function…”
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Integrative network analysis highlights biological processes underlying GLP-1 stimulated insulin secretion: A DIRECT study by Gudmundsdottir, Valborg, Pedersen, Helle Krogh, Allebrandt, Karla Viviani, Brorsson, Caroline, van Leeuwen, Nienke, Banasik, Karina, Mahajan, Anubha, Groves, Christopher J, van de Bunt, Martijn, Dawed, Adem Y, Fritsche, Andreas, Staiger, Harald, Simonis-Bik, Annemarie M C, Deelen, Joris, Kramer, Mark H H, Dietrich, Axel, Hübschle, Thomas, Willemsen, Gonneke, Häring, Hans-Ulrich, de Geus, Eco J C, Boomsma, Dorret I, Eekhoff, Elisabeth M W, Ferrer, Jorge, McCarthy, Mark I, Pearson, Ewan R, Gupta, Ramneek, Brunak, Søren, 't Hart, Leen M

“…Glucagon-like peptide 1 (GLP-1) stimulated insulin secretion has a considerable heritable component as estimated from twin studies, yet few genetic variants…”
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Genetic association analysis of 13 nuclear-encoded mitochondrial candidate genes with type II diabetes mellitus: the DAMAGE study by REILING, Erwin, VAN VLIET-OSTAPTCHOUK, Jana V, SMIT, Jan Wa, NIJPELS, Giel, HEINE, Robert J, UITTERLINDEN, André G, PEDERSEN, Oluf, SLAGBOOM, P. Eline, MAASSEN, Johannes A, HOFKER, Marten H, M 'T HART, Leen, DEKKER, Jacqueline M, VAN 'T RIET, Esther, VAN HAEFTEN, Timon W, ARP, Pascal A, HANSEN, Torben, KREMER, Dennis, GROENEWOUD, Marlous J, VAN HOVE, Els C, ROMIJN, Johannes A

“…Mitochondria play an important role in many processes, like glucose metabolism, fatty acid oxidation and ATP synthesis. In this study, we aimed to identify…”
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